231813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1430039..1431078 Replicon chromosome
Accession NZ_CP090754
Organism Burkholderia multivorans strain 2010Ycf41

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag L0Z40_RS22065 Protein ID WP_105751292.1
Coordinates 1430039..1430614 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A8E2S2M5
Locus tag L0Z40_RS22070 Protein ID WP_053298663.1
Coordinates 1430611..1431078 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z40_RS22030 (L0Z40_22030) 1425115..1426197 + 1083 WP_105751297.1 porin -
L0Z40_RS22035 (L0Z40_22035) 1426333..1426833 - 501 WP_226823143.1 hypothetical protein -
L0Z40_RS22040 (L0Z40_22040) 1426830..1427069 - 240 WP_244131642.1 DUF6402 family protein -
L0Z40_RS22045 (L0Z40_22045) 1427421..1427534 + 114 Protein_1242 porin -
L0Z40_RS22050 (L0Z40_22050) 1427593..1428558 - 966 WP_105751295.1 zinc-binding alcohol dehydrogenase family protein -
L0Z40_RS22055 (L0Z40_22055) 1428638..1428889 - 252 WP_105751294.1 hypothetical protein -
L0Z40_RS22060 (L0Z40_22060) 1428985..1429794 + 810 WP_105751293.1 helix-turn-helix transcriptional regulator -
L0Z40_RS22065 (L0Z40_22065) 1430039..1430614 - 576 WP_105751292.1 PIN domain-containing protein Toxin
L0Z40_RS22070 (L0Z40_22070) 1430611..1431078 - 468 WP_053298663.1 helix-turn-helix domain-containing protein Antitoxin
L0Z40_RS22075 (L0Z40_22075) 1431194..1432000 - 807 WP_065495028.1 4-hydroxy-2-oxoheptanedioate aldolase -
L0Z40_RS22080 (L0Z40_22080) 1432008..1432811 - 804 WP_006402377.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
L0Z40_RS22085 (L0Z40_22085) 1432826..1433218 - 393 WP_105751291.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
L0Z40_RS22090 (L0Z40_22090) 1433254..1434102 - 849 WP_105751327.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
L0Z40_RS22095 (L0Z40_22095) 1434145..1435608 - 1464 WP_006403683.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21585.68 Da        Isoelectric Point: 4.8924

>T231813 WP_105751292.1 NZ_CP090754:c1430614-1430039 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLTAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL

Download         Length: 576 bp

>T231813 NZ_CP126955:c123192-122815 [Escherichia coli O78:H4]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGCCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17669.09 Da        Isoelectric Point: 5.8709

>AT231813 WP_053298663.1 NZ_CP090754:c1431078-1430611 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEAQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE

Download         Length: 468 bp

>AT231813 NZ_CP126955:c123650-123282 [Escherichia coli O78:H4]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References