Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 791170..791825 Replicon chromosome
Accession NZ_CP090754
Organism Burkholderia multivorans strain 2010Ycf41

Toxin (Protein)


Gene name vapC Uniprot ID B9BGY2
Locus tag L0Z40_RS19145 Protein ID WP_006403072.1
Coordinates 791406..791825 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9BGX6
Locus tag L0Z40_RS19140 Protein ID WP_006403071.1
Coordinates 791170..791409 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z40_RS19115 (L0Z40_19115) 786232..786375 - 144 WP_006409932.1 hypothetical protein -
L0Z40_RS19120 (L0Z40_19120) 786964..787167 + 204 WP_006403067.1 hypothetical protein -
L0Z40_RS19125 (L0Z40_19125) 787181..787864 - 684 WP_006396647.1 Fe2+-dependent dioxygenase -
L0Z40_RS19130 (L0Z40_19130) 787861..788616 - 756 WP_006403069.1 tetratricopeptide repeat protein -
L0Z40_RS19135 (L0Z40_19135) 788620..790866 - 2247 WP_006403070.1 TonB-dependent siderophore receptor -
L0Z40_RS19140 (L0Z40_19140) 791170..791409 + 240 WP_006403071.1 Arc family DNA-binding protein Antitoxin
L0Z40_RS19145 (L0Z40_19145) 791406..791825 + 420 WP_006403072.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z40_RS19150 (L0Z40_19150) 791959..793254 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Z40_RS19155 (L0Z40_19155) 793487..793621 + 135 WP_006396654.1 entericidin A/B family lipoprotein -
L0Z40_RS19160 (L0Z40_19160) 793715..794290 - 576 WP_006403074.1 hypothetical protein -
L0Z40_RS19165 (L0Z40_19165) 794485..795435 - 951 WP_105752205.1 DMT family transporter -
L0Z40_RS19170 (L0Z40_19170) 795862..796656 - 795 WP_006403076.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15086.28 Da        Isoelectric Point: 5.2157

>T231810 WP_006403072.1 NZ_CP090754:791406-791825 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T231810 NZ_CP126954:62196-62348 [Escherichia coli O78:H4]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8698.91 Da        Isoelectric Point: 5.1133

>AT231810 WP_006403071.1 NZ_CP090754:791170-791409 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPISFE

Download         Length: 240 bp

>AT231810 NZ_CP126954:c62146-62084 [Escherichia coli O78:H4]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9BGY2

Antitoxin

Source ID Structure
AlphaFold DB B9BGX6

References