Detailed information of TA system TA231809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 628308..629578
• Replicon: chromosome
• Accession: NZ_CP090754
• Organism: Burkholderia multivorans strain 2010Ycf41

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z40_RS18470
• Protein ID: WP_105751379.1
• Coordinates: 628308..628886 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9BS12
• Locus tag: L0Z40_RS18475
• Protein ID: WP_006406126.1
• Coordinates: 629021..629578 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z40_RS18450 (L0Z40_18450)	623590..624381	+	792	WP_035947285.1	enoyl-CoA hydratase	-
L0Z40_RS18455 (L0Z40_18455)	624378..625517	+	1140	WP_006410588.1	enoyl-CoA hydratase/isomerase family protein	-
L0Z40_RS18460 (L0Z40_18460)	625564..626484	-	921	WP_065496151.1	LysR family transcriptional regulator	-
L0Z40_RS18465 (L0Z40_18465)	626663..628201	+	1539	WP_105751380.1	MFS transporter	-
L0Z40_RS18470 (L0Z40_18470)	628308..628886	-	579	WP_105751379.1	HD domain-containing protein	Toxin
L0Z40_RS18475 (L0Z40_18475)	629021..629578	-	558	WP_006406126.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z40_RS18480 (L0Z40_18480)	630091..631494	+	1404	WP_088929364.1	hypothetical protein	-
L0Z40_RS18485 (L0Z40_18485)	631505..632125	-	621	WP_006410617.1	isochorismatase family cysteine hydrolase	-
L0Z40_RS18490 (L0Z40_18490)	632260..633519	+	1260	WP_006401211.1	IS256-like element IS1356 family transposase	-
L0Z40_RS18495 (L0Z40_18495)	634073..634516	-	444	WP_223852633.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	632260..633519	1259

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (9-163)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21416.15 Da
• Isoelectric Point: 4.9434

>T231809 WP_105751379.1 NZ_CP090754:c628886-628308 [Burkholderia multivorans]
MNPDTIRVRLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Nucleotide

• Length: 579 bp

>T231809 NZ_CP126953:100598-101014 [Escherichia coli O78:H4]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20378.30 Da
• Isoelectric Point: 7.8341

>AT231809 WP_006406126.1 NZ_CP090754:c629578-629021 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT231809 NZ_CP126953:100371-100601 [Escherichia coli O78:H4]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: B9BS12