Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 737422..738055 Replicon chromosome
Accession NZ_CP090753
Organism Burkholderia multivorans strain 2010Ycf41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z40_RS03445 Protein ID WP_105767892.1
Coordinates 737642..738055 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z40_RS03440 Protein ID WP_085545763.1
Coordinates 737422..737655 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z40_RS03410 (L0Z40_03410) 732571..732822 - 252 Protein_664 AlpA family phage regulatory protein -
L0Z40_RS03415 (L0Z40_03415) 733126..733593 + 468 WP_105751502.1 TIR domain-containing protein -
L0Z40_RS03420 (L0Z40_03420) 733593..734219 + 627 WP_105751489.1 hypothetical protein -
L0Z40_RS03425 (L0Z40_03425) 734223..735362 + 1140 WP_105751490.1 nucleoside triphosphate pyrophosphohydrolase family protein -
L0Z40_RS03430 (L0Z40_03430) 735359..736021 + 663 WP_105751491.1 uracil-DNA glycosylase -
L0Z40_RS03435 (L0Z40_03435) 736420..737115 - 696 WP_105799419.1 phospholipase D family protein -
L0Z40_RS03440 (L0Z40_03440) 737422..737655 + 234 WP_085545763.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Z40_RS03445 (L0Z40_03445) 737642..738055 + 414 WP_105767892.1 PIN domain-containing protein Toxin
L0Z40_RS03450 (L0Z40_03450) 738090..738452 + 363 WP_105767921.1 DUF3742 family protein -
L0Z40_RS03455 (L0Z40_03455) 738574..739833 - 1260 WP_249458451.1 IS256-like element IS1356 family transposase -
L0Z40_RS03460 (L0Z40_03460) 739898..741331 - 1434 Protein_674 conjugal transfer protein TraG N-terminal domain-containing protein -
L0Z40_RS03465 (L0Z40_03465) 741344..741673 - 330 WP_105767975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 733593..745636 12043
- flank IS/Tn - - 738574..739833 1259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-120)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15293.73 Da        Isoelectric Point: 6.0823

>T231806 WP_105767892.1 NZ_CP090753:737642-738055 [Burkholderia multivorans]
MSGADKAKVFVDSNVVLYLLSGDAAKADRAEALLRRRPTISVQVLNEVTNVCVRKLGMAWREVDQFLELVRQFCVVAPLT
IEMHDLARRIAERYGLAFYDACIVAAASIEGCHALYTEDMHHGLIIEESLTLRNPFA

Download         Length: 414 bp

>T231806 NZ_CP126953:27263-27412 [Escherichia coli O78:H4]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8732.97 Da        Isoelectric Point: 7.0164

>AT231806 WP_085545763.1 NZ_CP090753:737422-737655 [Burkholderia multivorans]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVIDAPRTFAVRKKPGADELLERLRHFRGKLPADFKFSRDEANERG

Download         Length: 234 bp

>AT231806 NZ_CP126953:c27219-27158 [Escherichia coli O78:H4]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References