Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 9444..9921 Replicon plasmid p3_2010Ycf503
Accession NZ_CP090752
Organism Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag L0Z02_RS29850 Protein ID WP_249469239.1
Coordinates 9652..9921 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag L0Z02_RS29845 Protein ID WP_249469238.1
Coordinates 9444..9668 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z02_RS29820 (L0Z02_29820) 6310..6612 - 303 WP_249469262.1 hypothetical protein -
L0Z02_RS29825 (L0Z02_29825) 6609..6899 - 291 WP_249469264.1 hypothetical protein -
L0Z02_RS29830 (L0Z02_29830) 7208..7516 + 309 WP_005933969.1 hypothetical protein -
L0Z02_RS29835 (L0Z02_29835) 7513..9189 + 1677 WP_249469236.1 relaxase/mobilization nuclease domain-containing protein -
L0Z02_RS29840 (L0Z02_29840) 9146..9391 + 246 WP_249469266.1 hypothetical protein -
L0Z02_RS29845 (L0Z02_29845) 9444..9668 + 225 WP_249469238.1 TraY domain-containing protein Antitoxin
L0Z02_RS29850 (L0Z02_29850) 9652..9921 + 270 WP_249469239.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z02_RS29855 (L0Z02_29855) 9918..10196 + 279 WP_249469241.1 hypothetical protein -
L0Z02_RS29860 (L0Z02_29860) 10276..10530 + 255 WP_249469242.1 hypothetical protein -
L0Z02_RS29865 (L0Z02_29865) 10520..10840 + 321 WP_249469244.1 hypothetical protein -
L0Z02_RS29870 (L0Z02_29870) 10876..11382 - 507 WP_249469246.1 hypothetical protein -
L0Z02_RS29875 (L0Z02_29875) 11394..13586 - 2193 WP_249469248.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14081 14081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin

Relaxosome protein TraY

(4-49)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10481.22 Da        Isoelectric Point: 9.4993

>T231805 WP_249469239.1 NZ_CP090752:9652-9921 [Burkholderia multivorans]
MAYRIEIDPAAERELDKLDREIAKRILRFLFERVAKLDDPRSIGEALKGSKLGEFWKYRVGDYRIIADIQDGVLCILVLR
VGNRREVYR

Download         Length: 270 bp

>T231805 NZ_CP126953:c16567-16169 [Escherichia coli O78:H4]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8334.64 Da        Isoelectric Point: 4.5881

>AT231805 WP_249469238.1 NZ_CP090752:9444-9668 [Burkholderia multivorans]
MLAIRLPPEVESRLDALAAATGRTKTFLAREAILDNLDRLEDVYLAEQRLVDIRAGRTEPIPLEDVMKKYGLPD

Download         Length: 225 bp

>AT231805 NZ_CP126953:c16794-16567 [Escherichia coli O78:H4]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References