Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 67595..68253 Replicon plasmid p1_2010Ycf503
Accession NZ_CP090750
Organism Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z02_RS29125 Protein ID WP_105770420.1
Coordinates 67822..68253 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z02_RS29120 Protein ID WP_105770421.1
Coordinates 67595..67822 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z02_RS29095 (L0Z02_29095) 62873..63181 + 309 WP_105770425.1 hypothetical protein -
L0Z02_RS29100 (L0Z02_29100) 63178..63900 + 723 WP_105770424.1 hypothetical protein -
L0Z02_RS29105 (L0Z02_29105) 63902..66238 + 2337 WP_105770423.1 site-specific integrase -
L0Z02_RS29110 (L0Z02_29110) 66432..66926 + 495 WP_244143160.1 DUF2384 domain-containing protein -
L0Z02_RS29115 (L0Z02_29115) 66923..67396 + 474 WP_105770422.1 RES family NAD+ phosphorylase -
L0Z02_RS29120 (L0Z02_29120) 67595..67822 + 228 WP_105770421.1 CopG family transcriptional regulator Antitoxin
L0Z02_RS29125 (L0Z02_29125) 67822..68253 + 432 WP_105770420.1 PIN domain-containing protein Toxin
L0Z02_RS29130 (L0Z02_29130) 68642..71455 - 2814 WP_249469139.1 AAA family ATPase -
L0Z02_RS29135 (L0Z02_29135) 71779..72213 + 435 WP_006402598.1 conjugal transfer protein TraD -
L0Z02_RS29140 (L0Z02_29140) 72328..72558 - 231 WP_249469141.1 hypothetical protein -
L0Z02_RS29145 (L0Z02_29145) 72755..72922 - 168 WP_006402601.1 hypothetical protein -
L0Z02_RS29150 (L0Z02_29150) 72951..73121 - 171 WP_006402602.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..106647 106647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15516.89 Da        Isoelectric Point: 7.2772

>T231803 WP_105770420.1 NZ_CP090750:67822-68253 [Burkholderia multivorans]
MTYLLDVNVLIALLDPAHVQHEPAHAWFGQVGHAAWATCPLTENGVLRIIGNPKYPNAMGSPASVAPLVAQLRTHAGHTF
WPDDVSLLDVKHVDATRLLSSAQLTDTYLLALARAHKGKLATFDRRLVVDAVPHGAKHLELIS

Download         Length: 432 bp

>T231803 NZ_CP126952:c4673941-4673768 [Escherichia coli O78:H4]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8064.14 Da        Isoelectric Point: 8.9793

>AT231803 WP_105770421.1 NZ_CP090750:67595-67822 [Burkholderia multivorans]
MRTTIDIDDDVLAFARERAKPGTSIGKVISDLARAALQRTTANQSSRNGLPLMPVSAAARPVTLDTVNQLRDDSL

Download         Length: 228 bp

>AT231803 NZ_CP126952:c4674265-4673969 [Escherichia coli O78:H4]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAGTTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References