Detailed information of TA system TA231800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1522629..1523284
• Replicon: chromosome
• Accession: NZ_CP090748
• Organism: Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z02_RS23100
• Protein ID: WP_217232676.1
• Coordinates: 1522629..1523048 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L0Z02_RS23105
• Protein ID: WP_065496259.1
• Coordinates: 1523045..1523284 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z02_RS23075 (L0Z02_23075)	1517690..1518484	+	795	WP_059938960.1	AraC family transcriptional regulator	-
L0Z02_RS23080 (L0Z02_23080)	1519018..1519968	+	951	WP_249467813.1	DMT family transporter	-
L0Z02_RS23085 (L0Z02_23085)	1520164..1520739	+	576	WP_249467815.1	permease	-
L0Z02_RS23090 (L0Z02_23090)	1520833..1520967	-	135	WP_006409923.1	entericidin A/B family lipoprotein	-
L0Z02_RS23095 (L0Z02_23095)	1521200..1522495	+	1296	WP_035487510.1	aspartate carbamoyltransferase	-
L0Z02_RS23100 (L0Z02_23100)	1522629..1523048	-	420	WP_217232676.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z02_RS23105 (L0Z02_23105)	1523045..1523284	-	240	WP_065496259.1	Arc family DNA-binding protein	Antitoxin
L0Z02_RS23110 (L0Z02_23110)	1523590..1525836	+	2247	WP_249467817.1	TonB-dependent siderophore receptor	-
L0Z02_RS23115 (L0Z02_23115)	1525840..1526595	+	756	WP_006403069.1	tetratricopeptide repeat protein	-
L0Z02_RS23120 (L0Z02_23120)	1526592..1527275	+	684	WP_006409924.1	Fe2+-dependent dioxygenase	-
L0Z02_RS23125 (L0Z02_23125)	1527289..1527492	-	204	WP_006403067.1	hypothetical protein	-
L0Z02_RS23130 (L0Z02_23130)	1528081..1528224	+	144	WP_006409932.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15016.19 Da
• Isoelectric Point: 5.7470

>T231800 WP_217232676.1 NZ_CP090748:c1523048-1522629 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Nucleotide

• Length: 420 bp

>T231800 NZ_CP126952:c3886382-3886005 [Escherichia coli O78:H4]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8750.96 Da
• Isoelectric Point: 5.1133

>AT231800 WP_065496259.1 NZ_CP090748:c1523284-1523045 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Nucleotide

• Length: 240 bp

>AT231800 NZ_CP126952:c3886840-3886472 [Escherichia coli O78:H4]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCAACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA