Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1370812..1372559 Replicon chromosome
Accession NZ_CP090748
Organism Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag L0Z02_RS22390 Protein ID WP_065496359.1
Coordinates 1371663..1372559 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B9AZJ2
Locus tag L0Z02_RS22385 Protein ID WP_006396780.1
Coordinates 1370812..1371666 (-) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z02_RS22365 (L0Z02_22365) 1365983..1367473 - 1491 WP_088924112.1 aldehyde dehydrogenase -
L0Z02_RS22370 (L0Z02_22370) 1367535..1368365 - 831 WP_006403212.1 aspartate dehydrogenase -
L0Z02_RS22375 (L0Z02_22375) 1368358..1370025 - 1668 WP_053298420.1 thiamine pyrophosphate-binding protein -
L0Z02_RS22380 (L0Z02_22380) 1370018..1370815 - 798 WP_249467735.1 SDR family oxidoreductase -
L0Z02_RS22385 (L0Z02_22385) 1370812..1371666 - 855 WP_006396780.1 IclR family transcriptional regulator Antitoxin
L0Z02_RS22390 (L0Z02_22390) 1371663..1372559 - 897 WP_065496359.1 alpha/beta fold hydrolase Toxin
L0Z02_RS22395 (L0Z02_22395) 1372578..1373105 - 528 WP_006396778.1 cupin domain-containing protein -
L0Z02_RS22400 (L0Z02_22400) 1373133..1373903 - 771 WP_059940455.1 SDR family oxidoreductase -
L0Z02_RS22405 (L0Z02_22405) 1373896..1374966 - 1071 WP_249467736.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
L0Z02_RS22410 (L0Z02_22410) 1375014..1375325 - 312 WP_053298417.1 hypothetical protein -
L0Z02_RS22415 (L0Z02_22415) 1375327..1375644 - 318 WP_006396774.1 non-heme iron oxygenase ferredoxin subunit -
L0Z02_RS22420 (L0Z02_22420) 1376081..1377160 + 1080 WP_039217461.1 porin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(51-280)

Antitoxin

(23-71)


Sequences


Toxin        


Download         Length: 299 a.a.        Molecular weight: 30553.81 Da        Isoelectric Point: 8.0534

>T231799 WP_065496359.1 NZ_CP090748:c1372559-1371663 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA

Download         Length: 897 bp

>T231799 NZ_CP126952:3679717-3679935 [Escherichia coli O78:H4]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31176.75 Da        Isoelectric Point: 6.6558

>AT231799 WP_006396780.1 NZ_CP090748:c1371666-1370812 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT231799 NZ_CP126952:3679317-3679691 [Escherichia coli O78:H4]
ATGGATGAATACTCACCCAAAAGACATGATATCACGCAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB B9AZJ2

References