Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 945665..946680 | Replicon | chromosome |
| Accession | NZ_CP090748 | ||
| Organism | Burkholderia multivorans strain 2010Ycf503 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | L0Z02_RS20525 | Protein ID | WP_249468647.1 |
| Coordinates | 946129..946680 (+) | Length | 184 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A8E2S2M5 |
| Locus tag | L0Z02_RS20520 | Protein ID | WP_053298663.1 |
| Coordinates | 945665..946132 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z02_RS20495 (L0Z02_20495) | 941135..942598 | + | 1464 | WP_065495029.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
| L0Z02_RS20500 (L0Z02_20500) | 942641..943489 | + | 849 | WP_105800497.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| L0Z02_RS20505 (L0Z02_20505) | 943525..943917 | + | 393 | WP_006409445.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| L0Z02_RS20510 (L0Z02_20510) | 943932..944735 | + | 804 | WP_175685542.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| L0Z02_RS20515 (L0Z02_20515) | 944743..945549 | + | 807 | WP_035487732.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| L0Z02_RS20520 (L0Z02_20520) | 945665..946132 | + | 468 | WP_053298663.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L0Z02_RS20525 (L0Z02_20525) | 946129..946680 | + | 552 | WP_249468647.1 | PIN domain-containing protein | Toxin |
| L0Z02_RS20530 (L0Z02_20530) | 946706..947740 | + | 1035 | WP_006409625.1 | IS481 family transposase | - |
| L0Z02_RS20535 (L0Z02_20535) | 948052..948861 | - | 810 | WP_249468650.1 | helix-turn-helix transcriptional regulator | - |
| L0Z02_RS20540 (L0Z02_20540) | 948956..949207 | + | 252 | WP_039218251.1 | hypothetical protein | - |
| L0Z02_RS20545 (L0Z02_20545) | 949286..950251 | + | 966 | WP_249468652.1 | zinc-binding alcohol dehydrogenase family protein | - |
| L0Z02_RS20550 (L0Z02_20550) | 950310..950423 | - | 114 | Protein_850 | porin | - |
| L0Z02_RS20555 (L0Z02_20555) | 950434..950616 | + | 183 | WP_162097062.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 947117..947740 | 623 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 184 a.a. Molecular weight: 20598.57 Da Isoelectric Point: 4.8707
>T231797 WP_249468647.1 NZ_CP090748:946129-946680 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDAFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQMCDS
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDAFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQMCDS
Download Length: 552 bp
>T231797 NZ_CP126952:3261949-3262335 [Escherichia coli O78:H4]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAATCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAATCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17669.09 Da Isoelectric Point: 5.8709
>AT231797 WP_053298663.1 NZ_CP090748:945665-946132 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEAQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
MHHATTPDMILPVEREMQAAVEAQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
Download Length: 468 bp
>AT231797 NZ_CP126952:3262325-3262654 [Escherichia coli O78:H4]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|