Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 413643..414263 Replicon chromosome
Accession NZ_CP090748
Organism Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z02_RS18170 Protein ID WP_012217495.1
Coordinates 413946..414263 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z02_RS18165 Protein ID WP_006398012.1
Coordinates 413643..413942 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z02_RS18140 (L0Z02_18140) 408879..410150 + 1272 WP_105848030.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L0Z02_RS18145 (L0Z02_18145) 410165..410653 + 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z02_RS18150 (L0Z02_18150) 410671..410997 + 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z02_RS18155 (L0Z02_18155) 410987..412207 + 1221 WP_249468447.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z02_RS18160 (L0Z02_18160) 412322..413608 + 1287 WP_053297867.1 DUF445 domain-containing protein -
L0Z02_RS18165 (L0Z02_18165) 413643..413942 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z02_RS18170 (L0Z02_18170) 413946..414263 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z02_RS18175 (L0Z02_18175) 414628..416268 + 1641 WP_249468448.1 acetolactate synthase large subunit -
L0Z02_RS18180 (L0Z02_18180) 416297..417730 + 1434 WP_249468449.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231795 WP_012217495.1 NZ_CP090748:c414263-413946 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231795 NZ_CP126952:2895251-2895358 [Escherichia coli O78:H4]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231795 WP_006398012.1 NZ_CP090748:c413942-413643 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231795 NZ_CP126952:c2895198-2895137 [Escherichia coli O78:H4]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References