Detailed information of TA system TA231794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3411188..3411825
• Replicon: chromosome
• Accession: NZ_CP090747
• Organism: Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z02_RS15960
• Protein ID: WP_053296685.1
• Coordinates: 3411188..3411589 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: L0Z02_RS15965
• Protein ID: WP_006408845.1
• Coordinates: 3411589..3411825 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z02_RS15950 (L0Z02_15950)	3408509..3409651	+	1143	WP_070555436.1	alginate lyase family protein	-
L0Z02_RS15955 (L0Z02_15955)	3409678..3411066	+	1389	WP_006401425.1	L-serine ammonia-lyase	-
L0Z02_RS15960 (L0Z02_15960)	3411188..3411589	-	402	WP_053296685.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z02_RS15965 (L0Z02_15965)	3411589..3411825	-	237	WP_006408845.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z02_RS15970 (L0Z02_15970)	3412013..3413716	+	1704	WP_217253216.1	thiamine pyrophosphate-binding protein	-
L0Z02_RS15975 (L0Z02_15975)	3413713..3414801	+	1089	WP_249466567.1	ADP-heptose--LPS heptosyltransferase	-
L0Z02_RS15980 (L0Z02_15980)	3414920..3415951	-	1032	WP_012212492.1	helix-turn-helix domain-containing protein	-
L0Z02_RS15985 (L0Z02_15985)	3416122..3416664	-	543	WP_006408276.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14963.17 Da
• Isoelectric Point: 5.7429

>T231794 WP_053296685.1 NZ_CP090747:c3411589-3411188 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T231794 NZ_CP126952:c2602420-2602244 [Escherichia coli O78:H4]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT231794 WP_006408845.1 NZ_CP090747:c3411825-3411589 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT231794 NZ_CP126952:c2602200-2601784 [Escherichia coli O78:H4]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1