Detailed information of TA system TA231793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1012809..1013509
• Replicon: chromosome
• Accession: NZ_CP090747
• Organism: Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A8E2RY82
• Locus tag: L0Z02_RS04750
• Protein ID: WP_070553238.1
• Coordinates: 1013132..1013509 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z02_RS04745
• Protein ID: WP_006405635.1
• Coordinates: 1012809..1013132 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z02_RS04725 (L0Z02_04725)	1008158..1009618	+	1461	WP_059940736.1	PLP-dependent aminotransferase family protein	-
L0Z02_RS04730 (L0Z02_04730)	1009777..1011675	+	1899	WP_249467178.1	molecular chaperone HtpG	-
L0Z02_RS04735 (L0Z02_04735)	1011684..1012298	+	615	WP_105806826.1	chorismate lyase	-
L0Z02_RS04740 (L0Z02_04740)	1012295..1012786	+	492	WP_053296985.1	DNA-deoxyinosine glycosylase	-
L0Z02_RS04745 (L0Z02_04745)	1012809..1013132	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z02_RS04750 (L0Z02_04750)	1013132..1013509	-	378	WP_070553238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z02_RS04755 (L0Z02_04755)	1013494..1013703	+	210	WP_249467620.1	hypothetical protein	-
L0Z02_RS04760 (L0Z02_04760)	1014040..1014294	-	255	WP_249467180.1	hypothetical protein	-
L0Z02_RS04765 (L0Z02_04765)	1014523..1015440	+	918	WP_053296988.1	spermidine synthase	-
L0Z02_RS04770 (L0Z02_04770)	1015637..1015870	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z02_RS04775 (L0Z02_04775)	1015867..1017417	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z02_RS04780 (L0Z02_04780)	1017521..1017967	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13507.49 Da
• Isoelectric Point: 9.3081

>T231793 WP_070553238.1 NZ_CP090747:c1013509-1013132 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231793 NZ_CP126952:2516772-2518088 [Escherichia coli O78:H4]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGATCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAACAGCTCACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGTGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGCAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACCGTCGGTTAAGCCGAGAATGGTATTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231793 WP_006405635.1 NZ_CP090747:c1013132-1012809 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231793 NZ_CP126952:2516506-2516772 [Escherichia coli O78:H4]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACCTTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: B9BQB8