Detailed information of TA system TA231792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3322475..3323112
• Replicon: chromosome
• Accession: NZ_CP090746
• Organism: Burkholderia multivorans strain 2010Ycf576V

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8E2UU98
• Locus tag: L0Z34_RS28430
• Protein ID: WP_035489546.1
• Coordinates: 3322475..3322876 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: L0Z34_RS28435
• Protein ID: WP_006408845.1
• Coordinates: 3322876..3323112 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z34_RS28420 (L0Z34_28420)	3319796..3320938	+	1143	WP_006408286.1	alginate lyase family protein	-
L0Z34_RS28425 (L0Z34_28425)	3320965..3322353	+	1389	WP_006408285.1	L-serine ammonia-lyase	-
L0Z34_RS28430 (L0Z34_28430)	3322475..3322876	-	402	WP_035489546.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z34_RS28435 (L0Z34_28435)	3322876..3323112	-	237	WP_006408845.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z34_RS28440 (L0Z34_28440)	3323300..3325003	+	1704	WP_006408280.1	thiamine pyrophosphate-binding protein	-
L0Z34_RS28445 (L0Z34_28445)	3325000..3326088	+	1089	WP_006408279.1	hypothetical protein	-
L0Z34_RS28450 (L0Z34_28450)	3326207..3327238	-	1032	WP_045594318.1	helix-turn-helix domain-containing protein	-
L0Z34_RS28455 (L0Z34_28455)	3327409..3327951	-	543	WP_006408276.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15035.28 Da
• Isoelectric Point: 5.7429

>T231792 WP_035489546.1 NZ_CP090746:c3322876-3322475 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCTNPARERRNLAALIEDIPVAPFDVAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T231792 NZ_CP126952:2170455-2170557 [Escherichia coli O78:H4]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT231792 WP_006408845.1 NZ_CP090746:c3323112-3322876 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT231792 NZ_CP126952:c2170595-2170327 [Escherichia coli O78:H4]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1