Detailed information of TA system TA231790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 996941..997641
• Replicon: chromosome
• Accession: NZ_CP090746
• Organism: Burkholderia multivorans strain 2010Ycf576V

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9BQB7
• Locus tag: L0Z34_RS17405
• Protein ID: WP_006405634.1
• Coordinates: 997264..997641 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z34_RS17400
• Protein ID: WP_006405635.1
• Coordinates: 996941..997264 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z34_RS17380 (L0Z34_17380)	992290..993750	+	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-
L0Z34_RS17385 (L0Z34_17385)	993909..995807	+	1899	WP_006409758.1	molecular chaperone HtpG	-
L0Z34_RS17390 (L0Z34_17390)	995816..996430	+	615	WP_006398690.1	chorismate lyase	-
L0Z34_RS17395 (L0Z34_17395)	996427..996918	+	492	WP_006409760.1	DNA-deoxyinosine glycosylase	-
L0Z34_RS17400 (L0Z34_17400)	996941..997264	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z34_RS17405 (L0Z34_17405)	997264..997641	-	378	WP_006405634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z34_RS17410 (L0Z34_17410)	998170..998424	-	255	WP_035488690.1	hypothetical protein	-
L0Z34_RS17415 (L0Z34_17415)	998652..999569	+	918	WP_006405631.1	spermidine synthase	-
L0Z34_RS17420 (L0Z34_17420)	999766..999999	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z34_RS17425 (L0Z34_17425)	999996..1001546	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z34_RS17430 (L0Z34_17430)	1001650..1002096	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13564.63 Da
• Isoelectric Point: 9.7722

>T231790 WP_006405634.1 NZ_CP090746:c997641-997264 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGLGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231790 NZ_CP126952:1903555-1903809 [Escherichia coli O78:H4]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231790 WP_006405635.1 NZ_CP090746:c997264-996941 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231790 NZ_CP126952:1903307-1903558 [Escherichia coli O78:H4]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: B9BQB7

Antitoxin

• AlphaFold DB: B9BQB8