Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1566647..1567236 Replicon chromosome
Accession NZ_CP090745
Organism Burkholderia multivorans strain 2010Ycf576V

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z34_RS09350 Protein ID WP_006409935.1
Coordinates 1566647..1567066 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z34_RS09355 Protein ID WP_174328801.1
Coordinates 1567063..1567236 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z34_RS09325 (L0Z34_09325) 1561722..1562516 + 795 WP_006409930.1 AraC family transcriptional regulator -
L0Z34_RS09330 (L0Z34_09330) 1563029..1563979 + 951 WP_172488721.1 DMT family transporter -
L0Z34_RS09335 (L0Z34_09335) 1564183..1564758 + 576 WP_006409927.1 hypothetical protein -
L0Z34_RS09340 (L0Z34_09340) 1564852..1564986 - 135 WP_006409923.1 entericidin A/B family lipoprotein -
L0Z34_RS09345 (L0Z34_09345) 1565219..1566514 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Z34_RS09350 (L0Z34_09350) 1566647..1567066 - 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z34_RS09355 (L0Z34_09355) 1567063..1567236 - 174 WP_174328801.1 plasmid stability protein Antitoxin
L0Z34_RS09360 (L0Z34_09360) 1567520..1569766 + 2247 WP_006403070.1 TonB-dependent siderophore receptor -
L0Z34_RS09365 (L0Z34_09365) 1569770..1570525 + 756 WP_006403069.1 tetratricopeptide repeat protein -
L0Z34_RS09370 (L0Z34_09370) 1570522..1571205 + 684 WP_006409924.1 Fe2+-dependent dioxygenase -
L0Z34_RS09375 (L0Z34_09375) 1571219..1571422 - 204 WP_006403067.1 hypothetical protein -
L0Z34_RS09380 (L0Z34_09380) 1572011..1572154 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T231788 WP_006409935.1 NZ_CP090745:c1567066-1566647 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T231788 NZ_CP126952:1425250-1425648 [Escherichia coli O78:H4]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6298.07 Da        Isoelectric Point: 4.5184

>AT231788 WP_174328801.1 NZ_CP090745:c1567236-1567063 [Burkholderia multivorans]
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 174 bp

>AT231788 NZ_CP126952:1425023-1425250 [Escherichia coli O78:H4]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References