Detailed information of TA system TA231786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1131380..1131914
• Replicon: chromosome
• Accession: NZ_CP090745
• Organism: Burkholderia multivorans strain 2010Ycf576V

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Z34_RS07510
• Protein ID: WP_006411826.1
• Coordinates: 1131615..1131914 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9B0C2
• Locus tag: L0Z34_RS07505
• Protein ID: WP_006397060.1
• Coordinates: 1131380..1131625 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z34_RS07490 (L0Z34_07490)	1126431..1128134	+	1704	WP_006411824.1	VRR-NUC domain-containing protein	-
L0Z34_RS07495 (L0Z34_07495)	1128131..1130431	+	2301	WP_006411821.1	ATP-dependent DNA helicase	-
L0Z34_RS07500 (L0Z34_07500)	1130470..1131240	-	771	WP_006403543.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Z34_RS07505 (L0Z34_07505)	1131380..1131625	+	246	WP_006397060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Z34_RS07510 (L0Z34_07510)	1131615..1131914	+	300	WP_006411826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z34_RS07515 (L0Z34_07515)	1132023..1133324	-	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Z34_RS07520 (L0Z34_07520)	1133548..1134855	-	1308	WP_006411823.1	shikimate transporter	-
L0Z34_RS07525 (L0Z34_07525)	1135210..1136337	+	1128	WP_006403536.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11585.15 Da
• Isoelectric Point: 9.3671

>T231786 WP_006411826.1 NZ_CP090745:1131615-1131914 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWSYTYKRWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231786 NZ_CP126952:c686606-686142 [Escherichia coli O78:H4]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8662.73 Da
• Isoelectric Point: 6.4604

>AT231786 WP_006397060.1 NZ_CP090745:1131380-1131625 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231786 NZ_CP126952:c686941-686606 [Escherichia coli O78:H4]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: B9B0C2