231785

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 995929..996968 Replicon chromosome
Accession NZ_CP090745
Organism Burkholderia multivorans strain 2010Ycf576V

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag L0Z34_RS06890 Protein ID WP_045593318.1
Coordinates 996393..996968 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A8B3VE28
Locus tag L0Z34_RS06885 Protein ID WP_035946227.1
Coordinates 995929..996396 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z34_RS06860 (L0Z34_06860) 991399..992862 + 1464 WP_006409448.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -
L0Z34_RS06865 (L0Z34_06865) 992905..993753 + 849 WP_006409439.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
L0Z34_RS06870 (L0Z34_06870) 993789..994181 + 393 WP_006409445.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
L0Z34_RS06875 (L0Z34_06875) 994196..994999 + 804 WP_006402377.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
L0Z34_RS06880 (L0Z34_06880) 995007..995813 + 807 WP_035487732.1 4-hydroxy-2-oxoheptanedioate aldolase -
L0Z34_RS06885 (L0Z34_06885) 995929..996396 + 468 WP_035946227.1 helix-turn-helix domain-containing protein Antitoxin
L0Z34_RS06890 (L0Z34_06890) 996393..996968 + 576 WP_045593318.1 PIN domain-containing protein Toxin
L0Z34_RS06895 (L0Z34_06895) 997213..998022 - 810 WP_006409450.1 helix-turn-helix transcriptional regulator -
L0Z34_RS06900 (L0Z34_06900) 998118..998369 + 252 WP_006409444.1 hypothetical protein -
L0Z34_RS06905 (L0Z34_06905) 998448..999413 + 966 WP_006409441.1 zinc-binding alcohol dehydrogenase family protein -
L0Z34_RS06910 (L0Z34_06910) 999472..999585 - 114 Protein_894 porin -
L0Z34_RS06915 (L0Z34_06915) 999969..1001027 + 1059 WP_226823145.1 DUF6402 family protein -
L0Z34_RS06920 (L0Z34_06920) 1001041..1001541 + 501 WP_226823143.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21555.65 Da        Isoelectric Point: 4.8924

>T231785 WP_045593318.1 NZ_CP090745:996393-996968 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL

Download         Length: 576 bp

>T231785 NZ_CP126952:c426214-426107 [Escherichia coli O78:H4]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17655.06 Da        Isoelectric Point: 5.8709

>AT231785 WP_035946227.1 NZ_CP090745:995929-996396 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE

Download         Length: 468 bp

>AT231785 NZ_CP126952:426263-426329 [Escherichia coli O78:H4]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3VE28

References