Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 404961..405581 Replicon chromosome
Accession NZ_CP090745
Organism Burkholderia multivorans strain 2010Ycf576V

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z34_RS04315 Protein ID WP_012217495.1
Coordinates 405264..405581 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z34_RS04310 Protein ID WP_006398012.1
Coordinates 404961..405260 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z34_RS04285 (L0Z34_04285) 400199..401470 + 1272 WP_006411366.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L0Z34_RS04290 (L0Z34_04290) 401485..401973 + 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z34_RS04295 (L0Z34_04295) 401991..402317 + 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z34_RS04300 (L0Z34_04300) 402307..403527 + 1221 WP_006411378.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z34_RS04305 (L0Z34_04305) 403642..404928 + 1287 WP_035487943.1 DUF445 domain-containing protein -
L0Z34_RS04310 (L0Z34_04310) 404961..405260 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z34_RS04315 (L0Z34_04315) 405264..405581 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z34_RS04320 (L0Z34_04320) 405944..407584 + 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z34_RS04325 (L0Z34_04325) 407613..409046 + 1434 WP_006404214.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231784 WP_012217495.1 NZ_CP090745:c405581-405264 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231784 NZ_CP126952:c425248-425141 [Escherichia coli O78:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231784 WP_006398012.1 NZ_CP090745:c405260-404961 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231784 NZ_CP126952:425297-425363 [Escherichia coli O78:H4]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References