Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1922554..1923174 Replicon chromosome
Accession NZ_CP090742
Organism Burkholderia multivorans strain 2010Ycf635

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z21_RS26895 Protein ID WP_012217495.1
Coordinates 1922554..1922871 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z21_RS26900 Protein ID WP_006398012.1
Coordinates 1922875..1923174 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z21_RS26885 (L0Z21_26885) 1919087..1920520 - 1434 WP_069221287.1 aldehyde dehydrogenase family protein -
L0Z21_RS26890 (L0Z21_26890) 1920549..1922189 - 1641 WP_249461028.1 acetolactate synthase large subunit -
L0Z21_RS26895 (L0Z21_26895) 1922554..1922871 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z21_RS26900 (L0Z21_26900) 1922875..1923174 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z21_RS26905 (L0Z21_26905) 1923209..1924495 - 1287 WP_035487943.1 DUF445 domain-containing protein -
L0Z21_RS26910 (L0Z21_26910) 1924610..1925830 - 1221 WP_069221288.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z21_RS26915 (L0Z21_26915) 1925820..1926146 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z21_RS26920 (L0Z21_26920) 1926164..1926652 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z21_RS26925 (L0Z21_26925) 1926667..1927938 - 1272 WP_069221289.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231783 WP_012217495.1 NZ_CP090742:1922554-1922871 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231783 NZ_CP126952:c424765-424658 [Escherichia coli O78:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231783 WP_006398012.1 NZ_CP090742:1922875-1923174 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231783 NZ_CP126952:424822-424880 [Escherichia coli O78:H4]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References