Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 903145..904892 Replicon chromosome
Accession NZ_CP090742
Organism Burkholderia multivorans strain 2010Ycf635

Toxin (Protein)


Gene name doc Uniprot ID B9BHC0
Locus tag L0Z21_RS22500 Protein ID WP_006403210.1
Coordinates 903145..904041 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B9AZJ2
Locus tag L0Z21_RS22505 Protein ID WP_006396780.1
Coordinates 904038..904892 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z21_RS22470 (L0Z21_22470) 898544..899623 - 1080 WP_069221008.1 porin -
L0Z21_RS22475 (L0Z21_22475) 900060..900377 + 318 WP_053298416.1 non-heme iron oxygenase ferredoxin subunit -
L0Z21_RS22480 (L0Z21_22480) 900379..900690 + 312 WP_053298417.1 hypothetical protein -
L0Z21_RS22485 (L0Z21_22485) 900738..901808 + 1071 WP_006403208.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
L0Z21_RS22490 (L0Z21_22490) 901801..902571 + 771 WP_059940455.1 SDR family oxidoreductase -
L0Z21_RS22495 (L0Z21_22495) 902599..903126 + 528 WP_006396778.1 cupin domain-containing protein -
L0Z21_RS22500 (L0Z21_22500) 903145..904041 + 897 WP_006403210.1 alpha/beta fold hydrolase Toxin
L0Z21_RS22505 (L0Z21_22505) 904038..904892 + 855 WP_006396780.1 IclR family transcriptional regulator Antitoxin
L0Z21_RS22510 (L0Z21_22510) 904889..905686 + 798 WP_069221009.1 SDR family oxidoreductase -
L0Z21_RS22515 (L0Z21_22515) 905679..907346 + 1668 WP_053298420.1 thiamine pyrophosphate-binding protein -
L0Z21_RS22520 (L0Z21_22520) 907339..908169 + 831 WP_006403212.1 aspartate dehydrogenase -
L0Z21_RS22525 (L0Z21_22525) 908231..909721 + 1491 WP_006403213.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30544.80 Da        Isoelectric Point: 8.0446

>T231781 WP_006403210.1 NZ_CP090742:903145-904041 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA

Download         Length: 897 bp

>T231781 NZ_CP126952:c317428-317051 [Escherichia coli O78:H4]
ATGACCATTCAGTTTATCTCAGCGGAGGAGATAATTTATTTCCACGATAAATTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTATGAGTATGAAGGCGTTTCTGATCTTT
GGTTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATCTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCATCATACTTGCTGCAAACCCAGAGTTTGTAGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACGCGGTACCTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31176.75 Da        Isoelectric Point: 6.6558

>AT231781 WP_006396780.1 NZ_CP090742:904038-904892 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT231781 NZ_CP126952:c317646-317425 [Escherichia coli O78:H4]
ATGCATACCATGAACTACAGCGAAGCGCGGCAGAACCTTGCATTAGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCAGCTGTGATTATCAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CAGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTAAGGAGTTAGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9BHC0

Antitoxin

Source ID Structure
AlphaFold DB B9AZJ2

References