Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1939105..1939705 Replicon chromosome
Accession NC_011365
Organism Gluconacetobacter diazotrophicus PAl 5

Toxin (Protein)


Gene name relE Uniprot ID A9HCY6
Locus tag GDIA_RS08830 Protein ID WP_012223960.1
Coordinates 1939361..1939705 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5YEQ9
Locus tag GDIA_RS08825 Protein ID WP_010511780.1
Coordinates 1939105..1939368 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDIA_RS08800 1934874..1936102 + 1229 WP_157864211.1 IS3-like element ISGdi14 family transposase -
GDIA_RS08805 1936280..1936762 - 483 WP_012223951.1 Hsp20 family protein -
GDIA_RS08815 1937085..1937909 + 825 WP_012553437.1 IS5-like element ISGdi2 family transposase -
GDIA_RS19520 1938126..1938227 + 102 WP_124296136.1 YXWGXW repeat-containing protein -
GDIA_RS08820 1938748..1938996 + 249 WP_010511782.1 hypothetical protein -
GDIA_RS08825 1939105..1939368 + 264 WP_010511780.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GDIA_RS08830 1939361..1939705 + 345 WP_012223960.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GDIA_RS08835 1939738..1940415 + 678 Protein_1776 recombinase family protein -
GDIA_RS08840 1940468..1941664 - 1197 WP_012553962.1 IS256-like element ISGdi8 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1818917..1935901 116984
- inside IScluster/Tn - - 1931078..1943005 11927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13319.12 Da        Isoelectric Point: 9.9550

>T23178 WP_012223960.1 NC_011365:1939361-1939705 [Gluconacetobacter diazotrophicus PA1 5]
MTEYAIEFDDRALREWDGLDGSIRRKFEKKLEKLVLNPHSPGNELHGDLAGFYKIKLRQDGYRLVYQVVEQRIVIFVIAV
GRREDNEIYTAATGRIPETPADRTRQPSSRSRKR

Download         Length: 345 bp

>T23178 NC_011365:1939361-1939705 [Gluconacetobacter diazotrophicus PA1 5]
ATGACTGAATACGCGATCGAATTCGATGATCGCGCACTTCGGGAATGGGACGGGCTTGACGGCAGCATTCGCAGGAAGTT
CGAGAAAAAGCTCGAAAAACTGGTTCTGAACCCGCATTCTCCCGGTAACGAACTGCACGGCGATCTCGCGGGATTCTACA
AGATCAAGCTGCGGCAGGACGGCTATCGCCTTGTCTATCAGGTCGTGGAACAGCGGATCGTCATCTTCGTCATCGCGGTC
GGACGCCGCGAGGACAACGAAATCTACACGGCGGCAACCGGGCGCATCCCGGAGACGCCAGCCGATCGGACACGTCAGCC
CAGCAGCAGAAGCCGCAAGAGGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9629.04 Da        Isoelectric Point: 7.3200

>AT23178 WP_010511780.1 NC_011365:1939105-1939368 [Gluconacetobacter diazotrophicus PA1 5]
MSAVTFRVDDALKSAAVAKLSAHGLSLSDVLRDTLAYIAETGQPPVKRRLVTDEDARLIEIVRERLADPAPRHRMTLAEL
KARHPDD

Download         Length: 264 bp

>AT23178 NC_011365:1939105-1939368 [Gluconacetobacter diazotrophicus PA1 5]
ATGTCCGCCGTGACGTTCCGTGTCGATGACGCCCTCAAATCCGCCGCTGTCGCCAAACTCTCCGCGCACGGCCTGTCTCT
CTCCGACGTCCTGCGCGATACCCTGGCCTATATCGCCGAGACCGGCCAGCCACCGGTCAAGCGGCGGCTTGTGACCGACG
AAGATGCAAGGCTGATCGAAATCGTCCGAGAACGCCTCGCCGATCCCGCCCCCCGCCACCGCATGACGCTGGCGGAACTC
AAGGCGCGCCATCCGGATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9HCY6

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4J448

References