Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
Location | 261171..261766 | Replicon | chromosome |
Accession | NZ_CP090742 | ||
Organism | Burkholderia multivorans strain 2010Ycf635 |
Toxin (Protein)
Gene name | chpB | Uniprot ID | B9B2F6 |
Locus tag | L0Z21_RS19660 | Protein ID | WP_006397259.1 |
Coordinates | 261171..261521 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | chpS | Uniprot ID | B9B2F5 |
Locus tag | L0Z21_RS19665 | Protein ID | WP_006397258.1 |
Coordinates | 261515..261766 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0Z21_RS19650 (L0Z21_19650) | 256263..259448 | + | 3186 | WP_006397262.1 | multidrug efflux RND transporter permease subunit CeoB | - |
L0Z21_RS19655 (L0Z21_19655) | 259459..260991 | + | 1533 | WP_043279069.1 | multidrug efflux transporter outer membrane subunit OpcM | - |
L0Z21_RS19660 (L0Z21_19660) | 261171..261521 | - | 351 | WP_006397259.1 | type II toxin-antitoxin system ChpB family toxin | Toxin |
L0Z21_RS19665 (L0Z21_19665) | 261515..261766 | - | 252 | WP_006397258.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
L0Z21_RS19670 (L0Z21_19670) | 262323..263816 | - | 1494 | WP_249461094.1 | M81 family metallopeptidase | - |
L0Z21_RS19675 (L0Z21_19675) | 263917..265221 | - | 1305 | WP_039222447.1 | MFS transporter | - |
L0Z21_RS19680 (L0Z21_19680) | 265363..266334 | + | 972 | WP_006397255.1 | LysR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12423.44 Da Isoelectric Point: 8.9128
>T231778 WP_006397259.1 NZ_CP090742:c261521-261171 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREHQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE
MVKRVKFERGDIVRVSLNPTLGREHQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE
Download Length: 351 bp
>T231778 NZ_CP126950:77238-77390 [Escherichia coli O78:H4]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9007.36 Da Isoelectric Point: 6.2420
>AT231778 WP_006397258.1 NZ_CP090742:c261766-261515 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW
Download Length: 252 bp
>AT231778 NZ_CP126950:c77188-77126 [Escherichia coli O78:H4]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | B9B2F6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A132EKI4 |