Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 261171..261766 Replicon chromosome
Accession NZ_CP090742
Organism Burkholderia multivorans strain 2010Ycf635

Toxin (Protein)


Gene name chpB Uniprot ID B9B2F6
Locus tag L0Z21_RS19660 Protein ID WP_006397259.1
Coordinates 261171..261521 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID B9B2F5
Locus tag L0Z21_RS19665 Protein ID WP_006397258.1
Coordinates 261515..261766 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z21_RS19650 (L0Z21_19650) 256263..259448 + 3186 WP_006397262.1 multidrug efflux RND transporter permease subunit CeoB -
L0Z21_RS19655 (L0Z21_19655) 259459..260991 + 1533 WP_043279069.1 multidrug efflux transporter outer membrane subunit OpcM -
L0Z21_RS19660 (L0Z21_19660) 261171..261521 - 351 WP_006397259.1 type II toxin-antitoxin system ChpB family toxin Toxin
L0Z21_RS19665 (L0Z21_19665) 261515..261766 - 252 WP_006397258.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Z21_RS19670 (L0Z21_19670) 262323..263816 - 1494 WP_249461094.1 M81 family metallopeptidase -
L0Z21_RS19675 (L0Z21_19675) 263917..265221 - 1305 WP_039222447.1 MFS transporter -
L0Z21_RS19680 (L0Z21_19680) 265363..266334 + 972 WP_006397255.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12423.44 Da        Isoelectric Point: 8.9128

>T231778 WP_006397259.1 NZ_CP090742:c261521-261171 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREHQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T231778 NZ_CP126950:77238-77390 [Escherichia coli O78:H4]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9007.36 Da        Isoelectric Point: 6.2420

>AT231778 WP_006397258.1 NZ_CP090742:c261766-261515 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT231778 NZ_CP126950:c77188-77126 [Escherichia coli O78:H4]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9B2F6

Antitoxin

Source ID Structure
AlphaFold DB A0A132EKI4

References