Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 3335221..3335858 Replicon chromosome
Accession NZ_CP090740
Organism Burkholderia multivorans strain 2010Ycf635

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z21_RS15800 Protein ID WP_069219848.1
Coordinates 3335221..3335622 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag L0Z21_RS15805 Protein ID WP_069219847.1
Coordinates 3335622..3335858 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z21_RS15790 (L0Z21_15790) 3332542..3333684 + 1143 WP_053296686.1 alginate lyase family protein -
L0Z21_RS15795 (L0Z21_15795) 3333711..3335099 + 1389 WP_006408285.1 L-serine ammonia-lyase -
L0Z21_RS15800 (L0Z21_15800) 3335221..3335622 - 402 WP_069219848.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z21_RS15805 (L0Z21_15805) 3335622..3335858 - 237 WP_069219847.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z21_RS15810 (L0Z21_15810) 3336046..3337749 + 1704 WP_069219846.1 thiamine pyrophosphate-binding protein -
L0Z21_RS15815 (L0Z21_15815) 3337746..3338843 + 1098 WP_069219845.1 ADP-heptose--LPS heptosyltransferase -
L0Z21_RS15820 (L0Z21_15820) 3338962..3339993 - 1032 WP_012212492.1 helix-turn-helix domain-containing protein -
L0Z21_RS15825 (L0Z21_15825) 3340164..3340706 - 543 WP_006408276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14949.15 Da        Isoelectric Point: 5.7429

>T231777 WP_069219848.1 NZ_CP090740:c3335622-3335221 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAVTYAELEYGVTLCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Download         Length: 402 bp

>T231777 NZ_CP126950:13092-13370 [Escherichia coli O78:H4]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8946.01 Da        Isoelectric Point: 5.8651

>AT231777 WP_069219847.1 NZ_CP090740:c3335858-3335622 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRQLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Download         Length: 237 bp

>AT231777 NZ_CP126950:12823-13092 [Escherichia coli O78:H4]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References