Detailed information of TA system TA231776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3228401..3228957
• Replicon: chromosome
• Accession: NZ_CP090740
• Organism: Burkholderia multivorans strain 2010Ycf635

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Z21_RS15275
• Protein ID: WP_232348286.1
• Coordinates: 3228706..3228957 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: L0Z21_RS15270
• Protein ID: WP_004541313.1
• Coordinates: 3228401..3228679 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z21_RS15240 (L0Z21_15240)	3223526..3224293	+	768	WP_249460726.1	replication protein RepA	-
L0Z21_RS15245 (L0Z21_15245)	3224347..3225132	-	786	WP_006397377.1	IS21-like element helper ATPase IstB	-
L0Z21_RS15250 (L0Z21_15250)	3225129..3226151	-	1023	WP_011875632.1	IS21 family transposase	-
L0Z21_RS15255 (L0Z21_15255)	3226153..3226497	+	345	WP_249460730.1	hypothetical protein	-
L0Z21_RS15260 (L0Z21_15260)	3226897..3227157	-	261	WP_043279733.1	hypothetical protein	-
L0Z21_RS29190	3227785..3227916	+	132	WP_006401349.1	hypothetical protein	-
L0Z21_RS15265 (L0Z21_15265)	3227913..3228320	+	408	WP_237706316.1	hypothetical protein	-
L0Z21_RS15270 (L0Z21_15270)	3228401..3228679	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
L0Z21_RS15275 (L0Z21_15275)	3228706..3228957	+	252	WP_232348286.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z21_RS15280 (L0Z21_15280)	3228960..3229274	+	315	WP_043279737.1	hypothetical protein	-
L0Z21_RS29195	3229267..3229401	+	135	WP_261503824.1	hypothetical protein	-
L0Z21_RS15285 (L0Z21_15285)	3229471..3229743	+	273	WP_043279739.1	hypothetical protein	-
L0Z21_RS15290 (L0Z21_15290)	3229811..3230878	+	1068	WP_043279740.1	PIN domain-containing protein	-
L0Z21_RS15295 (L0Z21_15295)	3230948..3231469	-	522	WP_006401353.1	hypothetical protein	-
L0Z21_RS15300 (L0Z21_15300)	3231479..3232825	-	1347	WP_249460733.1	DotA/TraY family protein	-
L0Z21_RS15305 (L0Z21_15305)	3232820..3233779	+	960	Protein_2997	IS481 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3223526..3239112	15586

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9579.94 Da
• Isoelectric Point: 9.9718

>T231776 WP_232348286.1 NZ_CP090740:3228706-3228957 [Burkholderia multivorans]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231776 NZ_CP126948:c4801521-4801210 [Escherichia coli O78:H4]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT231776 WP_004541313.1 NZ_CP090740:3228401-3228679 [Burkholderia multivorans]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT231776 NZ_CP126948:c4801209-4800919 [Escherichia coli O78:H4]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: M4UBZ0