Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 2296407..2297053 Replicon chromosome
Accession NZ_CP090738
Organism Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z22_RS27150 Protein ID WP_249453716.1
Coordinates 2296407..2296814 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A8E1SEV4
Locus tag L0Z22_RS27155 Protein ID WP_059623347.1
Coordinates 2296811..2297053 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z22_RS27135 (L0Z22_27135) 2292833..2293963 - 1131 WP_249453713.1 porin -
L0Z22_RS27140 (L0Z22_27140) 2294226..2294804 + 579 WP_249453714.1 thioesterase family protein -
L0Z22_RS27145 (L0Z22_27145) 2294823..2296310 + 1488 WP_249453715.1 aldehyde dehydrogenase -
L0Z22_RS27150 (L0Z22_27150) 2296407..2296814 - 408 WP_249453716.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z22_RS27155 (L0Z22_27155) 2296811..2297053 - 243 WP_059623347.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z22_RS27160 (L0Z22_27160) 2297313..2297996 + 684 WP_060341578.1 phospholipase -
L0Z22_RS27165 (L0Z22_27165) 2298046..2299557 - 1512 WP_060056156.1 amino acid permease -
L0Z22_RS27170 (L0Z22_27170) 2299664..2301070 - 1407 WP_021161379.1 aspartate ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14791.93 Da        Isoelectric Point: 5.9816

>T231772 WP_249453716.1 NZ_CP090738:c2296814-2296407 [Burkholderia cepacia]
MKFLLDTNGVIAILKGEPAILSRLRSHQPGGFGIPAIVAHELYYGACKSQRVTANVARVEALQFEVVSFDVEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLITHDIREFERVPGLQVEDWLAEPREN

Download         Length: 408 bp

>T231772 NZ_CP126948:3620056-3620274 [Escherichia coli O78:H4]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8929.04 Da        Isoelectric Point: 4.7335

>AT231772 WP_059623347.1 NZ_CP090738:c2297053-2296811 [Burkholderia cepacia]
MDIAKIFKHGGSQAVRLPKDFRFDTAEVRIRRHGSSVVLEPVPQDWAWLTPLIGPVDADFEAAATTQPSAQERPDPDVFE

Download         Length: 243 bp

>AT231772 NZ_CP126948:3619656-3620030 [Escherichia coli O78:H4]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References