Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1576356..1576995 Replicon chromosome
Accession NZ_CP090738
Organism Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z22_RS24030 Protein ID WP_230962748.1
Coordinates 1576579..1576995 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2G525
Locus tag L0Z22_RS24025 Protein ID WP_021159426.1
Coordinates 1576356..1576592 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z22_RS24005 (L0Z22_24005) 1571458..1572231 + 774 WP_060341252.1 SDR family oxidoreductase -
L0Z22_RS24010 (L0Z22_24010) 1572302..1573537 - 1236 WP_060341253.1 acyltransferase -
L0Z22_RS24015 (L0Z22_24015) 1573834..1574577 - 744 WP_249455293.1 methyltransferase domain-containing protein -
L0Z22_RS24020 (L0Z22_24020) 1575122..1575959 + 838 Protein_1390 hypothetical protein -
L0Z22_RS24025 (L0Z22_24025) 1576356..1576592 + 237 WP_021159426.1 hypothetical protein Antitoxin
L0Z22_RS24030 (L0Z22_24030) 1576579..1576995 + 417 WP_230962748.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z22_RS24035 (L0Z22_24035) 1577195..1578091 + 897 WP_048025080.1 VOC family protein -
L0Z22_RS24040 (L0Z22_24040) 1578101..1578994 + 894 WP_042975012.1 CoA-transferase -
L0Z22_RS24045 (L0Z22_24045) 1579005..1579802 + 798 WP_048025082.1 ketoacid CoA transferase -
L0Z22_RS24050 (L0Z22_24050) 1579811..1580731 + 921 WP_249455294.1 enoyl-CoA hydratase -
L0Z22_RS24055 (L0Z22_24055) 1580728..1581828 + 1101 WP_059707397.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15278.57 Da        Isoelectric Point: 8.5855

>T231769 WP_230962748.1 NZ_CP090738:1576579-1576995 [Burkholderia cepacia]
VYLIDTNVISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWVAMILAGYAPNI
LPVDIEISQTWGHLRVPDPTHELDKLIAATALINDLTVVTRNVADFARTGVRLLNPFD

Download         Length: 417 bp

>T231769 NZ_CP126948:2953791-2954285 [Escherichia coli O78:H4]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGATCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8681.75 Da        Isoelectric Point: 5.8214

>AT231769 WP_021159426.1 NZ_CP090738:1576356-1576592 [Burkholderia cepacia]
MANLLVRNVDDNIVQSLRERAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGEDADFQRIQDSGEARRVFD

Download         Length: 237 bp

>AT231769 NZ_CP126948:2953501-2953794 [Escherichia coli O78:H4]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTATCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2G525

References