Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1213605..1215355 Replicon chromosome
Accession NZ_CP090738
Organism Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag L0Z22_RS22455 Protein ID WP_249455088.1
Coordinates 1213605..1214501 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A365QHE5
Locus tag L0Z22_RS22460 Protein ID WP_059497041.1
Coordinates 1214498..1215355 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z22_RS22420 (L0Z22_22420) 1208966..1210045 - 1080 WP_042976372.1 porin -
L0Z22_RS22425 (L0Z22_22425) 1210070..1210396 + 327 WP_249455086.1 hypothetical protein -
L0Z22_RS22430 (L0Z22_22430) 1210491..1210808 + 318 WP_021161517.1 non-heme iron oxygenase ferredoxin subunit -
L0Z22_RS22435 (L0Z22_22435) 1210812..1211123 + 312 WP_059484801.1 hypothetical protein -
L0Z22_RS22440 (L0Z22_22440) 1211192..1212262 + 1071 WP_021161515.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
L0Z22_RS22445 (L0Z22_22445) 1212255..1213025 + 771 WP_048022637.1 SDR family oxidoreductase -
L0Z22_RS22450 (L0Z22_22450) 1213059..1213586 + 528 WP_021161513.1 cupin domain-containing protein -
L0Z22_RS22455 (L0Z22_22455) 1213605..1214501 + 897 WP_249455088.1 alpha/beta fold hydrolase Toxin
L0Z22_RS22460 (L0Z22_22460) 1214498..1215355 + 858 WP_059497041.1 IclR family transcriptional regulator Antitoxin
L0Z22_RS22465 (L0Z22_22465) 1215352..1216149 + 798 WP_059484804.1 SDR family oxidoreductase -
L0Z22_RS22470 (L0Z22_22470) 1216142..1217809 + 1668 WP_021161509.1 thiamine pyrophosphate-binding protein -
L0Z22_RS22475 (L0Z22_22475) 1217802..1218629 + 828 WP_021161508.1 aspartate dehydrogenase -
L0Z22_RS22480 (L0Z22_22480) 1218702..1220192 + 1491 WP_059484807.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30584.78 Da        Isoelectric Point: 7.7509

>T231768 WP_249455088.1 NZ_CP090738:1213605-1214501 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRHCDQQRGLA

Download         Length: 897 bp

>T231768 NZ_CP126948:2838108-2838215 [Escherichia coli O78:H4]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31546.09 Da        Isoelectric Point: 6.6572

>AT231768 WP_059497041.1 NZ_CP090738:1214498-1215355 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRSLYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT231768 NZ_CP126948:c2838055-2837994 [Escherichia coli O78:H4]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A365QHE5

References