Detailed information of TA system TA231767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1015472..1016127
• Replicon: chromosome
• Accession: NZ_CP090738
• Organism: Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z22_RS21545
• Protein ID: WP_249454943.1
• Coordinates: 1015708..1016127 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: L0Z22_RS21540
• Protein ID: WP_021158161.1
• Coordinates: 1015472..1015711 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z22_RS21515 (L0Z22_21515)	1010743..1011138	-	396	WP_042973908.1	type II toxin-antitoxin system VapC family toxin	-
L0Z22_RS21520 (L0Z22_21520)	1011135..1011374	-	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L0Z22_RS21525 (L0Z22_21525)	1011464..1012147	-	684	WP_059650228.1	Fe2+-dependent dioxygenase	-
L0Z22_RS21530 (L0Z22_21530)	1012144..1012911	-	768	WP_249454938.1	tetratricopeptide repeat protein	-
L0Z22_RS21535 (L0Z22_21535)	1012915..1015161	-	2247	WP_249454941.1	TonB-dependent siderophore receptor	-
L0Z22_RS21540 (L0Z22_21540)	1015472..1015711	+	240	WP_021158161.1	antitoxin VapB	Antitoxin
L0Z22_RS21545 (L0Z22_21545)	1015708..1016127	+	420	WP_249454943.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z22_RS21550 (L0Z22_21550)	1016263..1017558	-	1296	WP_021158163.1	aspartate carbamoyltransferase	-
L0Z22_RS21555 (L0Z22_21555)	1017792..1017926	+	135	WP_021158165.1	entericidin A/B family lipoprotein	-
L0Z22_RS21560 (L0Z22_21560)	1018021..1018569	-	549	WP_021158166.1	hypothetical protein	-
L0Z22_RS21565 (L0Z22_21565)	1018755..1019708	-	954	WP_249455429.1	DMT family transporter	-
L0Z22_RS21570 (L0Z22_21570)	1020086..1020880	-	795	WP_249454945.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15182.54 Da
• Isoelectric Point: 5.9052

>T231767 WP_249454943.1 NZ_CP090738:1015708-1016127 [Burkholderia cepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGAAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T231767 NZ_CP126948:c2581858-2581682 [Escherichia coli O78:H4]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT231767 WP_021158161.1 NZ_CP090738:1015472-1015711 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT231767 NZ_CP126948:c2581638-2581222 [Escherichia coli O78:H4]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Structures

Antitoxin

• AlphaFold DB: U2HMP5