Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 860187..861408 Replicon chromosome
Accession NZ_CP090738
Organism Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)


Gene name vapC Uniprot ID U2FUP4
Locus tag L0Z22_RS20840 Protein ID WP_021162781.1
Coordinates 860187..860768 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A105CX23
Locus tag L0Z22_RS20845 Protein ID WP_059553061.1
Coordinates 860851..861408 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z22_RS20825 (L0Z22_20825) 855859..857919 - 2061 WP_249454842.1 MacB family efflux pump subunit -
L0Z22_RS20830 (L0Z22_20830) 857922..859115 - 1194 WP_249454844.1 macrolide transporter subunit MacA -
L0Z22_RS20835 (L0Z22_20835) 859403..860131 - 729 WP_059812766.1 class I SAM-dependent methyltransferase -
L0Z22_RS20840 (L0Z22_20840) 860187..860768 - 582 WP_021162781.1 HD domain-containing protein Toxin
L0Z22_RS20845 (L0Z22_20845) 860851..861408 - 558 WP_059553061.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z22_RS20850 (L0Z22_20850) 861463..862140 - 678 WP_059553059.1 hypothetical protein -
L0Z22_RS20855 (L0Z22_20855) 862501..863904 + 1404 WP_249454846.1 DUF308 domain-containing protein -
L0Z22_RS20860 (L0Z22_20860) 864001..864579 + 579 WP_021162777.1 hypothetical protein -
L0Z22_RS20865 (L0Z22_20865) 864661..865050 - 390 WP_175892155.1 OsmC family protein -
L0Z22_RS20870 (L0Z22_20870) 865281..866012 + 732 WP_124923717.1 ribonuclease T2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21256.86 Da        Isoelectric Point: 5.2812

>T231766 WP_021162781.1 NZ_CP090738:c860768-860187 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPAQRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGRNPPGFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDASGQHA

Download         Length: 582 bp

>T231766 NZ_CP126948:2496210-2497526 [Escherichia coli O78:H4]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGATCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAACAGCTCACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGTGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGCAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACCGTCGGTTAAGCCGAGAATGGTATTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20097.06 Da        Isoelectric Point: 10.2051

>AT231766 WP_059553061.1 NZ_CP090738:c861408-860851 [Burkholderia cepacia]
MSASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT231766 NZ_CP126948:2495944-2496210 [Escherichia coli O78:H4]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACCTTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2FUP4

Antitoxin

Source ID Structure
AlphaFold DB A0A105CX23

References