Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 173695..174214 Replicon chromosome
Accession NZ_CP090738
Organism Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)


Gene name relE Uniprot ID A0A2X1HSN6
Locus tag L0Z22_RS17825 Protein ID WP_059495132.1
Coordinates 173933..174214 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1IH73
Locus tag L0Z22_RS17820 Protein ID WP_059495134.1
Coordinates 173695..173943 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z22_RS17810 (L0Z22_17810) 171133..172326 + 1194 WP_059812057.1 2-methylaconitate cis-trans isomerase PrpF -
L0Z22_RS17815 (L0Z22_17815) 172520..173572 + 1053 WP_249454402.1 CaiB/BaiF CoA-transferase family protein -
L0Z22_RS17820 (L0Z22_17820) 173695..173943 + 249 WP_059495134.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L0Z22_RS17825 (L0Z22_17825) 173933..174214 + 282 WP_059495132.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z22_RS17830 (L0Z22_17830) 174243..174686 - 444 WP_011353771.1 PaaI family thioesterase -
L0Z22_RS17835 (L0Z22_17835) 174958..176577 + 1620 WP_048023840.1 methyl-accepting chemotaxis protein -
L0Z22_RS17840 (L0Z22_17840) 176550..177659 - 1110 WP_059553106.1 AGE family epimerase/isomerase -
L0Z22_RS17845 (L0Z22_17845) 177775..178473 + 699 WP_021159681.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10928.89 Da        Isoelectric Point: 10.6474

>T231764 WP_059495132.1 NZ_CP090738:173933-174214 [Burkholderia cepacia]
MTFELAFLEPALKEWKKLDRTVRDQFKAKLAERLEHPRIPSAKLHGHPDRYKIKLRGVGYRLVYEVRDAEVIVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T231764 NZ_CP126948:c1924878-1924504 [Escherichia coli O78:H4]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCATCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8991.33 Da        Isoelectric Point: 5.0636

>AT231764 WP_059495134.1 NZ_CP090738:173695-173943 [Burkholderia cepacia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAREKVVKVKLN
DL

Download         Length: 249 bp

>AT231764 NZ_CP126948:c1925335-1924967 [Escherichia coli O78:H4]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X1HSN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1IH73

References