Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1879471..1880144 Replicon chromosome
Accession NZ_CP090737
Organism Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)


Gene name vagD Uniprot ID U2G353
Locus tag L0Z22_RS08925 Protein ID WP_021160096.1
Coordinates 1879471..1879887 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID U2FLJ7
Locus tag L0Z22_RS08930 Protein ID WP_021160097.1
Coordinates 1879884..1880144 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z22_RS08905 (L0Z22_08905) 1875184..1875723 - 540 WP_249452222.1 outer membrane protein assembly factor BamE -
L0Z22_RS08910 (L0Z22_08910) 1875970..1877133 - 1164 WP_027787433.1 M20 aminoacylase family protein -
L0Z22_RS08915 (L0Z22_08915) 1877475..1878548 + 1074 WP_249453548.1 type IV toxin-antitoxin system AbiEi family antitoxin -
L0Z22_RS08920 (L0Z22_08920) 1878517..1879422 + 906 WP_104766674.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
L0Z22_RS08925 (L0Z22_08925) 1879471..1879887 - 417 WP_021160096.1 PIN domain-containing protein Toxin
L0Z22_RS08930 (L0Z22_08930) 1879884..1880144 - 261 WP_021160097.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z22_RS08935 (L0Z22_08935) 1880395..1881411 - 1017 WP_048020596.1 GNAT family N-acetyltransferase -
L0Z22_RS08940 (L0Z22_08940) 1881411..1882250 - 840 WP_249452223.1 formyltransferase family protein -
L0Z22_RS08945 (L0Z22_08945) 1882337..1884589 - 2253 WP_249452224.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14566.75 Da        Isoelectric Point: 7.8895

>T231762 WP_021160096.1 NZ_CP090737:c1879887-1879471 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T231762 NZ_CP126948:1910841-1911092 [Escherichia coli O78:H4]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9546.80 Da        Isoelectric Point: 4.6151

>AT231762 WP_021160097.1 NZ_CP090737:c1880144-1879884 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT231762 NZ_CP126948:1911089-1911343 [Escherichia coli O78:H4]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G353

Antitoxin

Source ID Structure
AlphaFold DB U2FLJ7

References