Detailed information of TA system TA231761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 975752..976434
• Replicon: chromosome
• Accession: NZ_CP090737
• Organism: Burkholderia cepacia strain 2011Ycf427V

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A2X2PQ15
• Locus tag: L0Z22_RS04615
• Protein ID: WP_048026588.1
• Coordinates: 976072..976434 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: L0Z22_RS04610
• Protein ID: WP_048026590.1
• Coordinates: 975752..976075 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z22_RS04590 (L0Z22_04590)	971137..972597	+	1461	WP_021158544.1	PLP-dependent aminotransferase family protein	-
L0Z22_RS04595 (L0Z22_04595)	972752..974650	+	1899	WP_059590634.1	molecular chaperone HtpG	-
L0Z22_RS04600 (L0Z22_04600)	974659..975258	+	600	WP_042974122.1	chorismate lyase	-
L0Z22_RS04605 (L0Z22_04605)	975258..975734	+	477	WP_249453191.1	DNA-deoxyinosine glycosylase	-
L0Z22_RS04610 (L0Z22_04610)	975752..976075	-	324	WP_048026590.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z22_RS04615 (L0Z22_04615)	976072..976434	-	363	WP_048026588.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z22_RS04620 (L0Z22_04620)	976758..977012	-	255	WP_021158550.1	hypothetical protein	-
L0Z22_RS04625 (L0Z22_04625)	977156..978073	+	918	WP_021158551.1	spermidine synthase-like protein	-
L0Z22_RS04630 (L0Z22_04630)	978272..978514	+	243	WP_021158552.1	DUF3311 domain-containing protein	-
L0Z22_RS04635 (L0Z22_04635)	978511..980061	+	1551	WP_048026582.1	sodium:solute symporter family protein	-
L0Z22_RS04640 (L0Z22_04640)	980122..980577	-	456	WP_059486351.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13176.02 Da
• Isoelectric Point: 9.5201

>T231761 WP_048026588.1 NZ_CP090737:c976434-976072 [Burkholderia cepacia]
MDPYIKPLYWLGSALKDLKAMPDAVQDTVGYALYLAQTGRKHDHAKPLRGFGSAGVLEIVESEDNGTYRAVYTVKLGNSV
YVLHSFQKKSSSGIATPKPDVDLIRERLKAAEAHAKGESR

Nucleotide

• Length: 363 bp

>T231761 NZ_CP126948:1391912-1392310 [Escherichia coli O78:H4]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.76 Da
• Isoelectric Point: 7.3600

>AT231761 WP_048026590.1 NZ_CP090737:c976075-975752 [Burkholderia cepacia]
MIEIEQGSGNVYADLGRHDADEMLVKAQLAAKIAEIIKARKWTQQHAARLLGMTQPKLSNMLRGQFRGVSETKMIECLAK
LGRDVQIVVGPDRHSEIEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231761 NZ_CP126948:1391685-1391912 [Escherichia coli O78:H4]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Structures

Toxin

• AlphaFold DB: A0A2X2PQ15