Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1897666..1898286 Replicon chromosome
Accession NZ_CP090735
Organism Burkholderia multivorans strain 2011Ycf521III

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z43_RS26640 Protein ID WP_012217495.1
Coordinates 1897666..1897983 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z43_RS26645 Protein ID WP_006398012.1
Coordinates 1897987..1898286 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z43_RS26630 (L0Z43_26630) 1894199..1895632 - 1434 WP_069221287.1 aldehyde dehydrogenase family protein -
L0Z43_RS26635 (L0Z43_26635) 1895661..1897301 - 1641 WP_249461028.1 acetolactate synthase large subunit -
L0Z43_RS26640 (L0Z43_26640) 1897666..1897983 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z43_RS26645 (L0Z43_26645) 1897987..1898286 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z43_RS26650 (L0Z43_26650) 1898321..1899607 - 1287 WP_035487943.1 DUF445 domain-containing protein -
L0Z43_RS26655 (L0Z43_26655) 1899722..1900942 - 1221 WP_069221288.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z43_RS26660 (L0Z43_26660) 1900932..1901258 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z43_RS26665 (L0Z43_26665) 1901276..1901764 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z43_RS26670 (L0Z43_26670) 1901779..1903050 - 1272 WP_069221289.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231760 WP_012217495.1 NZ_CP090735:1897666-1897983 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231760 NZ_CP126948:957350-957757 [Escherichia coli O78:H4]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231760 WP_006398012.1 NZ_CP090735:1897987-1898286 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231760 NZ_CP126948:957103-957369 [Escherichia coli O78:H4]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References