Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3360448..3361004 Replicon chromosome
Accession NZ_CP090733
Organism Burkholderia multivorans strain 2011Ycf521III

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag L0Z43_RS15815 Protein ID WP_232348286.1
Coordinates 3360753..3361004 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M4UBZ0
Locus tag L0Z43_RS15810 Protein ID WP_004541313.1
Coordinates 3360448..3360726 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z43_RS15775 (L0Z43_15775) 3355573..3356340 + 768 WP_249460726.1 replication protein RepA -
L0Z43_RS15780 (L0Z43_15780) 3356394..3357179 - 786 WP_006397377.1 IS21-like element helper ATPase IstB -
L0Z43_RS15785 (L0Z43_15785) 3357176..3358198 - 1023 WP_011875632.1 IS21 family transposase -
L0Z43_RS15790 (L0Z43_15790) 3358200..3358544 + 345 WP_249460730.1 hypothetical protein -
L0Z43_RS15795 (L0Z43_15795) 3358944..3359204 - 261 WP_043279733.1 hypothetical protein -
L0Z43_RS29010 3359832..3359963 + 132 WP_006401349.1 hypothetical protein -
L0Z43_RS15800 (L0Z43_15800) 3359908..3360252 + 345 WP_249460908.1 hypothetical protein -
L0Z43_RS15805 (L0Z43_15805) 3360224..3360367 + 144 WP_249460903.1 hypothetical protein -
L0Z43_RS15810 (L0Z43_15810) 3360448..3360726 + 279 WP_004541313.1 CopG family ribbon-helix-helix protein Antitoxin
L0Z43_RS15815 (L0Z43_15815) 3360753..3361004 + 252 WP_232348286.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z43_RS15820 (L0Z43_15820) 3361007..3361321 + 315 WP_043279737.1 hypothetical protein -
L0Z43_RS29015 3361314..3361448 + 135 WP_261503824.1 hypothetical protein -
L0Z43_RS15825 (L0Z43_15825) 3361518..3361790 + 273 WP_043279739.1 hypothetical protein -
L0Z43_RS15830 (L0Z43_15830) 3361858..3362925 + 1068 WP_043279740.1 PIN domain-containing protein -
L0Z43_RS15835 (L0Z43_15835) 3362995..3363516 - 522 WP_006401353.1 hypothetical protein -
L0Z43_RS15840 (L0Z43_15840) 3363526..3364872 - 1347 WP_249460733.1 DotA/TraY family protein -
L0Z43_RS15845 (L0Z43_15845) 3364867..3365826 + 960 Protein_3102 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3357176..3371159 13983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-81)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9579.94 Da        Isoelectric Point: 9.9718

>T231754 WP_232348286.1 NZ_CP090733:3360753-3361004 [Burkholderia multivorans]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDGDTVTILAVRHQKE
AGY

Download         Length: 252 bp

>T231754 NZ_CP126948:186121-186228 [Escherichia coli O78:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10810.11 Da        Isoelectric Point: 4.9736

>AT231754 WP_004541313.1 NZ_CP090733:3360448-3360726 [Burkholderia multivorans]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Download         Length: 279 bp

>AT231754 NZ_CP126948:c186072-186006 [Escherichia coli O78:H4]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB M4UBZ0

References