Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 2565448..2566970 Replicon chromosome
Accession NZ_CP090733
Organism Burkholderia multivorans strain 2011Ycf521III

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag L0Z43_RS11990 Protein ID WP_019397543.1
Coordinates 2566044..2566970 (+) Length 309 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag L0Z43_RS11985 Protein ID WP_217078439.1
Coordinates 2565448..2566047 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z43_RS11965 (L0Z43_11965) 2562461..2563129 + 669 WP_006400736.1 OmpA family protein -
L0Z43_RS11970 (L0Z43_11970) 2563284..2563982 + 699 WP_006400737.1 bifunctional 3-demethylubiquinone 3-O-methyltransferase/2-octaprenyl-6-hydroxy phenol methylase -
L0Z43_RS11975 (L0Z43_11975) 2563996..2564712 + 717 WP_012213845.1 phosphoglycolate phosphatase -
L0Z43_RS11985 (L0Z43_11985) 2565448..2566047 + 600 WP_217078439.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
L0Z43_RS11990 (L0Z43_11990) 2566044..2566970 + 927 WP_019397543.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
L0Z43_RS11995 (L0Z43_11995) 2566967..2567458 + 492 WP_217078432.1 hypothetical protein -
L0Z43_RS12000 (L0Z43_12000) 2567455..2568042 + 588 WP_217078431.1 hypothetical protein -
L0Z43_RS12005 (L0Z43_12005) 2568074..2568505 - 432 WP_217078430.1 LacI family transcriptional regulator -
L0Z43_RS12010 (L0Z43_12010) 2568502..2569857 - 1356 WP_249460597.1 recombinase family protein -
L0Z43_RS12015 (L0Z43_12015) 2569854..2570354 - 501 WP_217078770.1 DUF2924 domain-containing protein -
L0Z43_RS12020 (L0Z43_12020) 2570351..2570569 - 219 WP_217078769.1 hypothetical protein -
L0Z43_RS12025 (L0Z43_12025) 2570695..2571909 - 1215 WP_217078768.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-53)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 34471.36 Da        Isoelectric Point: 6.7011

>T231753 WP_019397543.1 NZ_CP090733:2566044-2566970 [Burkholderia multivorans]
VSKRNTAASVRARLLVKARTDKQDFNLVLTRYALERLLYRLSVSAHADHFLLKGALLFDLWFDIPHRPTRDADLLGFGSA
EIPHVEAAFREICAVELDDGIRFQADSVHAEEIRKEANYSGVRVTLLGLLDGARCHVQVDVGFGDAVTPGPEAVDYPVML
PDMPAPKLRAYPRYTVVAEKLEALVSLGIANSRMKDYFDLWILSRHSEFDGALLSKAIHATFERRRTPLPDGVPFGLSDE
FAQDRQKQTQWQAFLRKNALVELQLSEVIAGLRAFLSFPLDALRQAAAFPLAWRADSGWTPSTEESGR

Download         Length: 927 bp

>T231753 NZ_CP126948:185155-185262 [Escherichia coli O78:H4]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22296.91 Da        Isoelectric Point: 9.9667

>AT231753 WP_217078439.1 NZ_CP090733:2565448-2566047 [Burkholderia multivorans]
MDSSHQSILELAAQRGLIRPRDLNERGLPTVALTRLVRQGLLQRVGRGLYAIPDRPVSEHGALAEVARKNPQAIVCLLSA
LRVHELTTQSPFEVWLAIPNKARAPKMDYPPLRIVRFSGAALTEGIEEHSVDGVPVRVTNVARTVADCFKFRNKIGLDVA
LEALQEAWRAKRVSMDELWRFAELCRVANVMRPYLESLT

Download         Length: 600 bp

>AT231753 NZ_CP126948:c185106-185040 [Escherichia coli O78:H4]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References