Detailed information of TA system TA231752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1160334..1161016
• Replicon: chromosome
• Accession: NZ_CP090733
• Organism: Burkholderia multivorans strain 2011Ycf521III

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Z43_RS05465
• Protein ID: WP_069220063.1
• Coordinates: 1160657..1161016 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z43_RS05460
• Protein ID: WP_006405635.1
• Coordinates: 1160334..1160657 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z43_RS05440 (L0Z43_05440)	1155683..1157143	+	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-
L0Z43_RS05445 (L0Z43_05445)	1157302..1159200	+	1899	WP_069220062.1	molecular chaperone HtpG	-
L0Z43_RS05450 (L0Z43_05450)	1159209..1159823	+	615	WP_006398690.1	chorismate lyase	-
L0Z43_RS05455 (L0Z43_05455)	1159820..1160311	+	492	WP_053296985.1	DNA-deoxyinosine glycosylase	-
L0Z43_RS05460 (L0Z43_05460)	1160334..1160657	-	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z43_RS05465 (L0Z43_05465)	1160657..1161016	-	360	WP_069220063.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z43_RS05470 (L0Z43_05470)	1161564..1161818	-	255	WP_059940739.1	hypothetical protein	-
L0Z43_RS05475 (L0Z43_05475)	1162047..1162964	+	918	WP_053296988.1	spermidine synthase	-
L0Z43_RS05480 (L0Z43_05480)	1163161..1163394	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z43_RS05485 (L0Z43_05485)	1163391..1164941	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z43_RS05490 (L0Z43_05490)	1165045..1165491	-	447	WP_006405630.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 12917.82 Da
• Isoelectric Point: 9.3081

>T231752 WP_069220063.1 NZ_CP090733:c1161016-1160657 [Burkholderia multivorans]
MVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTVKLGGAV
YVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Nucleotide

• Length: 360 bp

>T231752 NZ_CP126947:124392-124790 [Escherichia coli O78:H51]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231752 WP_006405635.1 NZ_CP090733:c1160657-1160334 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231752 NZ_CP126947:124165-124392 [Escherichia coli O78:H51]
ATGGAAACCACCGTATTTTTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Structures

Antitoxin

• AlphaFold DB: B9BQB8