Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 84344..84981 Replicon chromosome
Accession NZ_CP090733
Organism Burkholderia multivorans strain 2011Ycf521III

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z43_RS00395 Protein ID WP_069219848.1
Coordinates 84344..84745 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag L0Z43_RS00400 Protein ID WP_069219847.1
Coordinates 84745..84981 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z43_RS00385 (L0Z43_00385) 81665..82807 + 1143 WP_053296686.1 alginate lyase family protein -
L0Z43_RS00390 (L0Z43_00390) 82834..84222 + 1389 WP_006408285.1 L-serine ammonia-lyase -
L0Z43_RS00395 (L0Z43_00395) 84344..84745 - 402 WP_069219848.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z43_RS00400 (L0Z43_00400) 84745..84981 - 237 WP_069219847.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z43_RS00405 (L0Z43_00405) 85169..86872 + 1704 WP_069219846.1 thiamine pyrophosphate-binding protein -
L0Z43_RS00410 (L0Z43_00410) 86869..87966 + 1098 WP_069219845.1 ADP-heptose--LPS heptosyltransferase -
L0Z43_RS00415 (L0Z43_00415) 88085..89116 - 1032 WP_012212492.1 helix-turn-helix domain-containing protein -
L0Z43_RS00420 (L0Z43_00420) 89287..89829 - 543 WP_006408276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14949.15 Da        Isoelectric Point: 5.7429

>T231751 WP_069219848.1 NZ_CP090733:c84745-84344 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAVTYAELEYGVTLCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Download         Length: 402 bp

>T231751 NZ_CP126947:c112429-112268 [Escherichia coli O78:H51]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTTGAACCGCCCCGGGTTTCCTGGAGAGTGTTTTATCTGT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8946.01 Da        Isoelectric Point: 5.8651

>AT231751 WP_069219847.1 NZ_CP090733:c84981-84745 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRQLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Download         Length: 237 bp

>AT231751 NZ_CP126947:112473-112534 [Escherichia coli O78:H51]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References