Detailed information of TA system TA231749

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 2307720..2308366
• Replicon: chromosome
• Accession: NZ_CP090732
• Organism: Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z05_RS33280
• Protein ID: WP_249453716.1
• Coordinates: 2307720..2308127 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A8E1SEV4
• Locus tag: L0Z05_RS33285
• Protein ID: WP_059623347.1
• Coordinates: 2308124..2308366 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z05_RS33265 (L0Z05_33265)	2304146..2305276	-	1131	WP_249453713.1	porin	-
L0Z05_RS33270 (L0Z05_33270)	2305539..2306117	+	579	WP_249453714.1	thioesterase family protein	-
L0Z05_RS33275 (L0Z05_33275)	2306136..2307623	+	1488	WP_249453715.1	aldehyde dehydrogenase	-
L0Z05_RS33280 (L0Z05_33280)	2307720..2308127	-	408	WP_249453716.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z05_RS33285 (L0Z05_33285)	2308124..2308366	-	243	WP_059623347.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z05_RS33290 (L0Z05_33290)	2308626..2309309	+	684	WP_060341578.1	phospholipase	-
L0Z05_RS33295 (L0Z05_33295)	2309359..2310870	-	1512	WP_060056156.1	amino acid permease	-
L0Z05_RS33300 (L0Z05_33300)	2310977..2312383	-	1407	WP_021161379.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14791.93 Da
• Isoelectric Point: 5.9816

>T231749 WP_249453716.1 NZ_CP090732:c2308127-2307720 [Burkholderia cepacia]
MKFLLDTNGVIAILKGEPAILSRLRSHQPGGFGIPAIVAHELYYGACKSQRVTANVARVEALQFEVVSFDVEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLITHDIREFERVPGLQVEDWLAEPREN

Nucleotide

• Length: 408 bp

>T231749 NZ_CP126947:92134-92550 [Escherichia coli O78:H51]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8929.04 Da
• Isoelectric Point: 4.7335

>AT231749 WP_059623347.1 NZ_CP090732:c2308366-2308124 [Burkholderia cepacia]
MDIAKIFKHGGSQAVRLPKDFRFDTAEVRIRRHGSSVVLEPVPQDWAWLTPLIGPVDADFEAAATTQPSAQERPDPDVFE

Nucleotide

• Length: 243 bp

>AT231749 NZ_CP126947:91907-92137 [Escherichia coli O78:H51]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGACCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA