Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1587663..1588302 Replicon chromosome
Accession NZ_CP090732
Organism Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z05_RS30160 Protein ID WP_230962748.1
Coordinates 1587886..1588302 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2G525
Locus tag L0Z05_RS30155 Protein ID WP_021159426.1
Coordinates 1587663..1587899 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z05_RS30135 (L0Z05_30135) 1582765..1583538 + 774 WP_060341252.1 SDR family oxidoreductase -
L0Z05_RS30140 (L0Z05_30140) 1583609..1584844 - 1236 WP_060341253.1 acyltransferase -
L0Z05_RS30145 (L0Z05_30145) 1585141..1585884 - 744 WP_249455293.1 methyltransferase domain-containing protein -
L0Z05_RS30150 (L0Z05_30150) 1586429..1587266 + 838 Protein_1400 hypothetical protein -
L0Z05_RS30155 (L0Z05_30155) 1587663..1587899 + 237 WP_021159426.1 hypothetical protein Antitoxin
L0Z05_RS30160 (L0Z05_30160) 1587886..1588302 + 417 WP_230962748.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z05_RS30165 (L0Z05_30165) 1588502..1589398 + 897 WP_048025080.1 VOC family protein -
L0Z05_RS30170 (L0Z05_30170) 1589408..1590301 + 894 WP_042975012.1 CoA-transferase -
L0Z05_RS30175 (L0Z05_30175) 1590312..1591109 + 798 WP_048025082.1 ketoacid CoA transferase -
L0Z05_RS30180 (L0Z05_30180) 1591118..1592038 + 921 WP_249455294.1 enoyl-CoA hydratase -
L0Z05_RS30185 (L0Z05_30185) 1592035..1593135 + 1101 WP_059707397.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15278.57 Da        Isoelectric Point: 8.5855

>T231746 WP_230962748.1 NZ_CP090732:1587886-1588302 [Burkholderia cepacia]
VYLIDTNVISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWVAMILAGYAPNI
LPVDIEISQTWGHLRVPDPTHELDKLIAATALINDLTVVTRNVADFARTGVRLLNPFD

Download         Length: 417 bp

>T231746 NZ_CP126946:4907150-4907461 [Escherichia coli O78:H51]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8681.75 Da        Isoelectric Point: 5.8214

>AT231746 WP_021159426.1 NZ_CP090732:1587663-1587899 [Burkholderia cepacia]
MANLLVRNVDDNIVQSLRERAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGEDADFQRIQDSGEARRVFD

Download         Length: 237 bp

>AT231746 NZ_CP126946:4907462-4907752 [Escherichia coli O78:H51]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2G525

References