Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1224909..1226659 | Replicon | chromosome |
| Accession | NZ_CP090732 | ||
| Organism | Burkholderia cepacia strain 2011Ycf793I | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | L0Z05_RS28585 | Protein ID | WP_249455088.1 |
| Coordinates | 1224909..1225805 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A365QHE5 |
| Locus tag | L0Z05_RS28590 | Protein ID | WP_059497041.1 |
| Coordinates | 1225802..1226659 (+) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z05_RS28550 (L0Z05_28550) | 1220270..1221349 | - | 1080 | WP_042976372.1 | porin | - |
| L0Z05_RS28555 (L0Z05_28555) | 1221374..1221700 | + | 327 | WP_249455086.1 | hypothetical protein | - |
| L0Z05_RS28560 (L0Z05_28560) | 1221795..1222112 | + | 318 | WP_021161517.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Z05_RS28565 (L0Z05_28565) | 1222116..1222427 | + | 312 | WP_059484801.1 | hypothetical protein | - |
| L0Z05_RS28570 (L0Z05_28570) | 1222496..1223566 | + | 1071 | WP_021161515.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Z05_RS28575 (L0Z05_28575) | 1223559..1224329 | + | 771 | WP_048022637.1 | SDR family oxidoreductase | - |
| L0Z05_RS28580 (L0Z05_28580) | 1224363..1224890 | + | 528 | WP_021161513.1 | cupin domain-containing protein | - |
| L0Z05_RS28585 (L0Z05_28585) | 1224909..1225805 | + | 897 | WP_249455088.1 | alpha/beta fold hydrolase | Toxin |
| L0Z05_RS28590 (L0Z05_28590) | 1225802..1226659 | + | 858 | WP_059497041.1 | IclR family transcriptional regulator | Antitoxin |
| L0Z05_RS28595 (L0Z05_28595) | 1226656..1227453 | + | 798 | WP_059484804.1 | SDR family oxidoreductase | - |
| L0Z05_RS28600 (L0Z05_28600) | 1227446..1229113 | + | 1668 | WP_021161509.1 | thiamine pyrophosphate-binding protein | - |
| L0Z05_RS28605 (L0Z05_28605) | 1229106..1229933 | + | 828 | WP_021161508.1 | aspartate dehydrogenase | - |
| L0Z05_RS28610 (L0Z05_28610) | 1230006..1231496 | + | 1491 | WP_059484807.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30584.78 Da Isoelectric Point: 7.7509
>T231745 WP_249455088.1 NZ_CP090732:1224909-1225805 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRHCDQQRGLA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRHCDQQRGLA
Download Length: 897 bp
>T231745 NZ_CP126946:4651728-4652105 [Escherichia coli O78:H51]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGTATCCGGAGGCAAAACGATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGTATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31546.09 Da Isoelectric Point: 6.6572
>AT231745 WP_059497041.1 NZ_CP090732:1225802-1226659 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRSLYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRSLYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR
Download Length: 858 bp
>AT231745 NZ_CP126946:4651271-4651639 [Escherichia coli O78:H51]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|