Detailed information of TA system TA231744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1026786..1027441
• Replicon: chromosome
• Accession: NZ_CP090732
• Organism: Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Z05_RS27675
• Protein ID: WP_249454943.1
• Coordinates: 1027022..1027441 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: L0Z05_RS27670
• Protein ID: WP_021158161.1
• Coordinates: 1026786..1027025 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z05_RS27645 (L0Z05_27645)	1022057..1022452	-	396	WP_042973908.1	type II toxin-antitoxin system VapC family toxin	-
L0Z05_RS27650 (L0Z05_27650)	1022449..1022688	-	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L0Z05_RS27655 (L0Z05_27655)	1022778..1023461	-	684	WP_059650228.1	Fe2+-dependent dioxygenase	-
L0Z05_RS27660 (L0Z05_27660)	1023458..1024225	-	768	WP_249454938.1	tetratricopeptide repeat protein	-
L0Z05_RS27665 (L0Z05_27665)	1024229..1026475	-	2247	WP_249454941.1	TonB-dependent siderophore receptor	-
L0Z05_RS27670 (L0Z05_27670)	1026786..1027025	+	240	WP_021158161.1	antitoxin VapB	Antitoxin
L0Z05_RS27675 (L0Z05_27675)	1027022..1027441	+	420	WP_249454943.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z05_RS27680 (L0Z05_27680)	1027577..1028872	-	1296	WP_021158163.1	aspartate carbamoyltransferase	-
L0Z05_RS27685 (L0Z05_27685)	1029106..1029240	+	135	WP_021158165.1	entericidin A/B family lipoprotein	-
L0Z05_RS27690 (L0Z05_27690)	1029335..1029883	-	549	WP_021158166.1	hypothetical protein	-
L0Z05_RS27695 (L0Z05_27695)	1030069..1031022	-	954	WP_249455429.1	DMT family transporter	-
L0Z05_RS27700 (L0Z05_27700)	1031388..1032182	-	795	WP_249454945.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15182.54 Da
• Isoelectric Point: 5.9052

>T231744 WP_249454943.1 NZ_CP090732:1027022-1027441 [Burkholderia cepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGAAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T231744 NZ_CP126946:c4364240-4364010 [Escherichia coli O78:H51]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT231744 WP_021158161.1 NZ_CP090732:1026786-1027025 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT231744 NZ_CP126946:c4364013-4363654 [Escherichia coli O78:H51]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: U2HMP5