Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 871501..872722 Replicon chromosome
Accession NZ_CP090732
Organism Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)


Gene name vapC Uniprot ID U2FUP4
Locus tag L0Z05_RS26970 Protein ID WP_021162781.1
Coordinates 871501..872082 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A105CX23
Locus tag L0Z05_RS26975 Protein ID WP_059553061.1
Coordinates 872165..872722 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z05_RS26955 (L0Z05_26955) 867173..869233 - 2061 WP_249454842.1 MacB family efflux pump subunit -
L0Z05_RS26960 (L0Z05_26960) 869236..870429 - 1194 WP_249454844.1 macrolide transporter subunit MacA -
L0Z05_RS26965 (L0Z05_26965) 870717..871445 - 729 WP_059812766.1 class I SAM-dependent methyltransferase -
L0Z05_RS26970 (L0Z05_26970) 871501..872082 - 582 WP_021162781.1 HD domain-containing protein Toxin
L0Z05_RS26975 (L0Z05_26975) 872165..872722 - 558 WP_059553061.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z05_RS26980 (L0Z05_26980) 872777..873454 - 678 WP_059553059.1 hypothetical protein -
L0Z05_RS26985 (L0Z05_26985) 873815..875218 + 1404 WP_249454846.1 DUF308 domain-containing protein -
L0Z05_RS26990 (L0Z05_26990) 875315..875893 + 579 WP_021162777.1 hypothetical protein -
L0Z05_RS26995 (L0Z05_26995) 875975..876364 - 390 WP_175892155.1 OsmC family protein -
L0Z05_RS27000 (L0Z05_27000) 876595..877326 + 732 WP_124923717.1 ribonuclease T2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21256.86 Da        Isoelectric Point: 5.2812

>T231743 WP_021162781.1 NZ_CP090732:c872082-871501 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPAQRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGRNPPGFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDASGQHA

Download         Length: 582 bp

>T231743 NZ_CP126946:c4342674-4342147 [Escherichia coli O78:H51]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20097.06 Da        Isoelectric Point: 10.2051

>AT231743 WP_059553061.1 NZ_CP090732:c872722-872165 [Burkholderia cepacia]
MSASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT231743 NZ_CP126946:c4342947-4342681 [Escherichia coli O78:H51]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2FUP4

Antitoxin

Source ID Structure
AlphaFold DB A0A105CX23

References