Detailed information of TA system TA231742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 359561..360126
• Replicon: chromosome
• Accession: NZ_CP090732
• Organism: Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8E1S7L3
• Locus tag: L0Z05_RS24790
• Protein ID: WP_060343311.1
• Coordinates: 359561..359932 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B1FGI9
• Locus tag: L0Z05_RS24795
• Protein ID: WP_006752328.1
• Coordinates: 359929..360126 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z05_RS24775 (L0Z05_24775)	355424..356149	+	726	WP_021159298.1	site-2 protease family protein	-
L0Z05_RS24780 (L0Z05_24780)	356212..357591	-	1380	WP_059591042.1	MFS transporter	-
L0Z05_RS24785 (L0Z05_24785)	357837..359414	+	1578	WP_249454468.1	aldehyde dehydrogenase (NADP(+))	-
L0Z05_RS24790 (L0Z05_24790)	359561..359932	-	372	WP_060343311.1	PIN domain-containing protein	Toxin
L0Z05_RS24795 (L0Z05_24795)	359929..360126	-	198	WP_006752328.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z05_RS24800 (L0Z05_24800)	360375..360926	+	552	WP_048023383.1	hypothetical protein	-
L0Z05_RS24805 (L0Z05_24805)	361110..362024	-	915	WP_048023382.1	5-dehydro-4-deoxyglucarate dehydratase	-
L0Z05_RS24810 (L0Z05_24810)	362253..363806	+	1554	WP_249454469.1	galactarate dehydratase	-
L0Z05_RS24815 (L0Z05_24815)	363873..364355	-	483	WP_042974910.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13384.42 Da
• Isoelectric Point: 5.5223

>T231742 WP_060343311.1 NZ_CP090732:c359932-359561 [Burkholderia cepacia]
MILVDTSVWIDHLRAGDATLTTLLEAERVLIHPFVVGELALGSLRDRETVLDALRDLPAAAAATDDEVQRMIDVAPLYGL
GIGYVDAHLLASVRLTSGSKLWTRDRRLLAAAERLQLAAHPAH

Nucleotide

• Length: 372 bp

>T231742 NZ_CP126946:4037096-4037560 [Escherichia coli O78:H51]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7054.10 Da
• Isoelectric Point: 10.6826

>AT231742 WP_006752328.1 NZ_CP090732:c360126-359929 [Burkholderia cepacia]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSEPA

Nucleotide

• Length: 198 bp

>AT231742 NZ_CP126946:4036761-4037096 [Escherichia coli O78:H51]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KMB8