Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 185015..185534 Replicon chromosome
Accession NZ_CP090732
Organism Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)


Gene name relE Uniprot ID A0A2X1HSN6
Locus tag L0Z05_RS23960 Protein ID WP_059495132.1
Coordinates 185253..185534 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1IH73
Locus tag L0Z05_RS23955 Protein ID WP_059495134.1
Coordinates 185015..185263 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z05_RS23945 (L0Z05_23945) 182453..183646 + 1194 WP_059812057.1 2-methylaconitate cis-trans isomerase PrpF -
L0Z05_RS23950 (L0Z05_23950) 183840..184892 + 1053 WP_249454402.1 CaiB/BaiF CoA-transferase family protein -
L0Z05_RS23955 (L0Z05_23955) 185015..185263 + 249 WP_059495134.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L0Z05_RS23960 (L0Z05_23960) 185253..185534 + 282 WP_059495132.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z05_RS23965 (L0Z05_23965) 185563..186006 - 444 WP_011353771.1 PaaI family thioesterase -
L0Z05_RS23970 (L0Z05_23970) 186278..187897 + 1620 WP_048023840.1 methyl-accepting chemotaxis protein -
L0Z05_RS23975 (L0Z05_23975) 187870..188979 - 1110 WP_059553106.1 AGE family epimerase/isomerase -
L0Z05_RS23980 (L0Z05_23980) 189095..189793 + 699 WP_021159681.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10928.89 Da        Isoelectric Point: 10.6474

>T231741 WP_059495132.1 NZ_CP090732:185253-185534 [Burkholderia cepacia]
MTFELAFLEPALKEWKKLDRTVRDQFKAKLAERLEHPRIPSAKLHGHPDRYKIKLRGVGYRLVYEVRDAEVIVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T231741 NZ_CP126946:3839217-3839594 [Escherichia coli O78:H51]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8991.33 Da        Isoelectric Point: 5.0636

>AT231741 WP_059495134.1 NZ_CP090732:185015-185263 [Burkholderia cepacia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAREKVVKVKLN
DL

Download         Length: 249 bp

>AT231741 NZ_CP126946:3838759-3839127 [Escherichia coli O78:H51]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCTCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGTCGACCGCGCCGGCATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X1HSN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1IH73

References