231740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2253598..2254271 Replicon chromosome
Accession NZ_CP090730
Organism Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)


Gene name vagD Uniprot ID U2G353
Locus tag L0Z05_RS10725 Protein ID WP_021160096.1
Coordinates 2253598..2254014 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID U2FLJ7
Locus tag L0Z05_RS10730 Protein ID WP_021160097.1
Coordinates 2254011..2254271 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z05_RS10705 (L0Z05_10705) 2249311..2249850 - 540 WP_249452222.1 outer membrane protein assembly factor BamE -
L0Z05_RS10710 (L0Z05_10710) 2250097..2251260 - 1164 WP_027787433.1 M20 aminoacylase family protein -
L0Z05_RS10715 (L0Z05_10715) 2251602..2252675 + 1074 WP_249453548.1 type IV toxin-antitoxin system AbiEi family antitoxin -
L0Z05_RS10720 (L0Z05_10720) 2252644..2253549 + 906 WP_104766674.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
L0Z05_RS10725 (L0Z05_10725) 2253598..2254014 - 417 WP_021160096.1 PIN domain-containing protein Toxin
L0Z05_RS10730 (L0Z05_10730) 2254011..2254271 - 261 WP_021160097.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z05_RS10735 (L0Z05_10735) 2254522..2255538 - 1017 WP_048020596.1 GNAT family N-acetyltransferase -
L0Z05_RS10740 (L0Z05_10740) 2255538..2256377 - 840 WP_249452223.1 formyltransferase family protein -
L0Z05_RS10745 (L0Z05_10745) 2256464..2258716 - 2253 WP_249452224.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14566.75 Da        Isoelectric Point: 7.8895

>T231740 WP_021160096.1 NZ_CP090730:c2254014-2253598 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T231740 NZ_CP126946:c3700208-3699801 [Escherichia coli O78:H51]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9546.80 Da        Isoelectric Point: 4.6151

>AT231740 WP_021160097.1 NZ_CP090730:c2254271-2254011 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT231740 NZ_CP126946:c3700455-3700189 [Escherichia coli O78:H51]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G353

Antitoxin

Source ID Structure
AlphaFold DB U2FLJ7

References