Detailed information of TA system TA231739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1349881..1350563
• Replicon: chromosome
• Accession: NZ_CP090730
• Organism: Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A2X2PQ15
• Locus tag: L0Z05_RS06415
• Protein ID: WP_048026588.1
• Coordinates: 1350201..1350563 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: L0Z05_RS06410
• Protein ID: WP_048026590.1
• Coordinates: 1349881..1350204 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z05_RS06390 (L0Z05_06390)	1345266..1346726	+	1461	WP_021158544.1	PLP-dependent aminotransferase family protein	-
L0Z05_RS06395 (L0Z05_06395)	1346881..1348779	+	1899	WP_059590634.1	molecular chaperone HtpG	-
L0Z05_RS06400 (L0Z05_06400)	1348788..1349387	+	600	WP_042974122.1	chorismate lyase	-
L0Z05_RS06405 (L0Z05_06405)	1349387..1349863	+	477	WP_249453191.1	DNA-deoxyinosine glycosylase	-
L0Z05_RS06410 (L0Z05_06410)	1349881..1350204	-	324	WP_048026590.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z05_RS06415 (L0Z05_06415)	1350201..1350563	-	363	WP_048026588.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z05_RS06420 (L0Z05_06420)	1350887..1351141	-	255	WP_021158550.1	hypothetical protein	-
L0Z05_RS06425 (L0Z05_06425)	1351285..1352202	+	918	WP_021158551.1	spermidine synthase-like protein	-
L0Z05_RS06430 (L0Z05_06430)	1352401..1352643	+	243	WP_021158552.1	DUF3311 domain-containing protein	-
L0Z05_RS06435 (L0Z05_06435)	1352640..1354190	+	1551	WP_048026582.1	sodium:solute symporter family protein	-
L0Z05_RS06440 (L0Z05_06440)	1354251..1354706	-	456	WP_059486351.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13176.02 Da
• Isoelectric Point: 9.5201

>T231739 WP_048026588.1 NZ_CP090730:c1350563-1350201 [Burkholderia cepacia]
MDPYIKPLYWLGSALKDLKAMPDAVQDTVGYALYLAQTGRKHDHAKPLRGFGSAGVLEIVESEDNGTYRAVYTVKLGNSV
YVLHSFQKKSSSGIATPKPDVDLIRERLKAAEAHAKGESR

Nucleotide

• Length: 363 bp

>T231739 NZ_CP126946:c3563874-3563539 [Escherichia coli O78:H51]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.76 Da
• Isoelectric Point: 7.3600

>AT231739 WP_048026590.1 NZ_CP090730:c1350204-1349881 [Burkholderia cepacia]
MIEIEQGSGNVYADLGRHDADEMLVKAQLAAKIAEIIKARKWTQQHAARLLGMTQPKLSNMLRGQFRGVSETKMIECLAK
LGRDVQIVVGPDRHSEIEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231739 NZ_CP126946:c3564122-3563874 [Escherichia coli O78:H51]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A2X2PQ15