Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1017116..1018155 Replicon chromosome
Accession NZ_CP090727
Organism Burkholderia multivorans strain 2014Y70439247

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag L0Z30_RS04615 Protein ID WP_105751292.1
Coordinates 1017580..1018155 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A8E2S2M5
Locus tag L0Z30_RS04610 Protein ID WP_053298663.1
Coordinates 1017116..1017583 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z30_RS04585 (L0Z30_04585) 1012586..1014049 + 1464 WP_006403683.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -
L0Z30_RS04590 (L0Z30_04590) 1014092..1014940 + 849 WP_105751327.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
L0Z30_RS04595 (L0Z30_04595) 1014976..1015368 + 393 WP_105751291.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
L0Z30_RS04600 (L0Z30_04600) 1015383..1016186 + 804 WP_006402377.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
L0Z30_RS04605 (L0Z30_04605) 1016194..1017000 + 807 WP_065495028.1 4-hydroxy-2-oxoheptanedioate aldolase -
L0Z30_RS04610 (L0Z30_04610) 1017116..1017583 + 468 WP_053298663.1 helix-turn-helix domain-containing protein Antitoxin
L0Z30_RS04615 (L0Z30_04615) 1017580..1018155 + 576 WP_105751292.1 PIN domain-containing protein Toxin
L0Z30_RS04620 (L0Z30_04620) 1018400..1019209 - 810 WP_105751293.1 helix-turn-helix transcriptional regulator -
L0Z30_RS04625 (L0Z30_04625) 1019305..1019556 + 252 WP_105751294.1 hypothetical protein -
L0Z30_RS04630 (L0Z30_04630) 1019636..1020601 + 966 WP_105751295.1 zinc-binding alcohol dehydrogenase family protein -
L0Z30_RS04635 (L0Z30_04635) 1020660..1020773 - 114 Protein_923 porin -
L0Z30_RS04640 (L0Z30_04640) 1021125..1021364 + 240 WP_244131642.1 DUF6402 family protein -
L0Z30_RS04645 (L0Z30_04645) 1021361..1021861 + 501 WP_226823143.1 hypothetical protein -
L0Z30_RS04650 (L0Z30_04650) 1021997..1023079 - 1083 WP_105751297.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21585.68 Da        Isoelectric Point: 4.8924

>T231730 WP_105751292.1 NZ_CP090727:1017580-1018155 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLTAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL

Download         Length: 576 bp

>T231730 NZ_CP126946:c1835350-1835243 [Escherichia coli O78:H51]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17669.09 Da        Isoelectric Point: 5.8709

>AT231730 WP_053298663.1 NZ_CP090727:1017116-1017583 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEAQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE

Download         Length: 468 bp

>AT231730 NZ_CP126946:1835403-1835464 [Escherichia coli O78:H51]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References