Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1525662..1527409 | Replicon | chromosome |
| Accession | NZ_CP090725 | ||
| Organism | Burkholderia multivorans strain 2014Y70518672I | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B9BHC0 |
| Locus tag | L0Z29_RS22580 | Protein ID | WP_006403210.1 |
| Coordinates | 1526513..1527409 (-) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Z29_RS22575 | Protein ID | WP_006396780.1 |
| Coordinates | 1525662..1526516 (-) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z29_RS22555 (L0Z29_22555) | 1520833..1522323 | - | 1491 | WP_105799370.1 | aldehyde dehydrogenase | - |
| L0Z29_RS22560 (L0Z29_22560) | 1522385..1523215 | - | 831 | WP_006403212.1 | aspartate dehydrogenase | - |
| L0Z29_RS22565 (L0Z29_22565) | 1523208..1524875 | - | 1668 | WP_053298420.1 | thiamine pyrophosphate-binding protein | - |
| L0Z29_RS22570 (L0Z29_22570) | 1524868..1525665 | - | 798 | WP_006409174.1 | SDR family oxidoreductase | - |
| L0Z29_RS22575 (L0Z29_22575) | 1525662..1526516 | - | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Z29_RS22580 (L0Z29_22580) | 1526513..1527409 | - | 897 | WP_006403210.1 | alpha/beta fold hydrolase | Toxin |
| L0Z29_RS22585 (L0Z29_22585) | 1527428..1527955 | - | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Z29_RS22590 (L0Z29_22590) | 1527983..1528753 | - | 771 | WP_105752056.1 | SDR family oxidoreductase | - |
| L0Z29_RS22595 (L0Z29_22595) | 1528746..1529816 | - | 1071 | WP_065496357.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Z29_RS22600 (L0Z29_22600) | 1529864..1530175 | - | 312 | WP_053298417.1 | hypothetical protein | - |
| L0Z29_RS22605 (L0Z29_22605) | 1530177..1530494 | - | 318 | WP_053298416.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Z29_RS22610 (L0Z29_22610) | 1530931..1532010 | + | 1080 | WP_006409825.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30544.80 Da Isoelectric Point: 8.0446
>T231726 WP_006403210.1 NZ_CP090725:c1527409-1526513 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
Download Length: 897 bp
>T231726 NZ_CP126946:c770006-769728 [Escherichia coli O78:H51]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231726 WP_006396780.1 NZ_CP090725:c1526516-1525662 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231726 NZ_CP126946:c770269-770009 [Escherichia coli O78:H51]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|