Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 996641..997680 Replicon chromosome
Accession NZ_CP090725
Organism Burkholderia multivorans strain 2014Y70518672I

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag L0Z29_RS20185 Protein ID WP_105751292.1
Coordinates 997105..997680 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A8E2S2M5
Locus tag L0Z29_RS20180 Protein ID WP_053298663.1
Coordinates 996641..997108 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z29_RS20155 (L0Z29_20155) 992111..993574 + 1464 WP_006403683.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -
L0Z29_RS20160 (L0Z29_20160) 993617..994465 + 849 WP_105751327.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
L0Z29_RS20165 (L0Z29_20165) 994501..994893 + 393 WP_105751291.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
L0Z29_RS20170 (L0Z29_20170) 994908..995711 + 804 WP_006402377.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
L0Z29_RS20175 (L0Z29_20175) 995719..996525 + 807 WP_065495028.1 4-hydroxy-2-oxoheptanedioate aldolase -
L0Z29_RS20180 (L0Z29_20180) 996641..997108 + 468 WP_053298663.1 helix-turn-helix domain-containing protein Antitoxin
L0Z29_RS20185 (L0Z29_20185) 997105..997680 + 576 WP_105751292.1 PIN domain-containing protein Toxin
L0Z29_RS20190 (L0Z29_20190) 997925..998734 - 810 WP_105751293.1 helix-turn-helix transcriptional regulator -
L0Z29_RS20195 (L0Z29_20195) 998830..999081 + 252 WP_105751294.1 hypothetical protein -
L0Z29_RS20200 (L0Z29_20200) 999161..1000126 + 966 WP_105751295.1 zinc-binding alcohol dehydrogenase family protein -
L0Z29_RS20205 (L0Z29_20205) 1000185..1000298 - 114 Protein_906 porin -
L0Z29_RS20210 (L0Z29_20210) 1000650..1000889 + 240 WP_244131642.1 DUF6402 family protein -
L0Z29_RS20215 (L0Z29_20215) 1000886..1001386 + 501 WP_226823143.1 hypothetical protein -
L0Z29_RS20220 (L0Z29_20220) 1001522..1002604 - 1083 WP_105751297.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21585.68 Da        Isoelectric Point: 4.8924

>T231724 WP_105751292.1 NZ_CP090725:997105-997680 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLTAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL

Download         Length: 576 bp

>T231724 NZ_CP126946:c104620-104210 [Escherichia coli O78:H51]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACAGGCCTGATGACACGTAA
TAACTACAGAATGGTAAATAACATTACCCTGGGTAGCATCCGGGGGCGAAACGATGAAACTTTCCCTGACGCTGGAAGCC
GACAGCGTTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17669.09 Da        Isoelectric Point: 5.8709

>AT231724 WP_053298663.1 NZ_CP090725:996641-997108 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEAQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE

Download         Length: 468 bp

>AT231724 NZ_CP126946:c105079-104711 [Escherichia coli O78:H51]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References