231721

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 1285051..1285751 Replicon chromosome
Accession NZ_CP090724
Organism Burkholderia multivorans strain 2014Y70518672I

Toxin (Protein)


Gene name tad Uniprot ID A0A8E2RY82
Locus tag L0Z29_RS06080 Protein ID WP_070553238.1
Coordinates 1285374..1285751 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID B9BQB8
Locus tag L0Z29_RS06075 Protein ID WP_006405635.1
Coordinates 1285051..1285374 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z29_RS06055 (L0Z29_06055) 1280400..1281860 + 1461 WP_006405639.1 PLP-dependent aminotransferase family protein -
L0Z29_RS06060 (L0Z29_06060) 1282019..1283917 + 1899 WP_059875776.1 molecular chaperone HtpG -
L0Z29_RS06065 (L0Z29_06065) 1283926..1284540 + 615 WP_006398690.1 chorismate lyase -
L0Z29_RS06070 (L0Z29_06070) 1284537..1285028 + 492 WP_006398691.1 DNA-deoxyinosine glycosylase -
L0Z29_RS06075 (L0Z29_06075) 1285051..1285374 - 324 WP_006405635.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z29_RS06080 (L0Z29_06080) 1285374..1285751 - 378 WP_070553238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z29_RS06085 (L0Z29_06085) 1286281..1286535 - 255 WP_059940739.1 hypothetical protein -
L0Z29_RS06090 (L0Z29_06090) 1286763..1287680 + 918 WP_053296988.1 spermidine synthase -
L0Z29_RS06095 (L0Z29_06095) 1287877..1288110 + 234 WP_006398697.1 DUF3311 domain-containing protein -
L0Z29_RS06100 (L0Z29_06100) 1288107..1289657 + 1551 WP_006398698.1 sodium:solute symporter family protein -
L0Z29_RS06105 (L0Z29_06105) 1289771..1290220 - 450 WP_105751509.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13507.49 Da        Isoelectric Point: 9.3081

>T231721 WP_070553238.1 NZ_CP090724:c1285751-1285374 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLSAAEAHANGEK

Download         Length: 378 bp

>T231721 NZ_CP126945:130577-130726 [Escherichia coli O1:K1:H7]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11828.69 Da        Isoelectric Point: 8.0686

>AT231721 WP_006405635.1 NZ_CP090724:c1285374-1285051 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Download         Length: 324 bp

>AT231721 NZ_CP126945:c130533-130472 [Escherichia coli O1:K1:H7]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B9BQB8

References